Essays about: "Proteases inhibitors"

Showing result 1 - 5 of 7 essays containing the words Proteases inhibitors.

1. 1. Studies of broad-spectrum inhibitors against main protease of SARS-CoV-2 and other Coronaviruses

   University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

   Author : Alexandra Stanciu; [2023]
   Keywords : human coronavirus 229E; SARS-CoV-2; main protease; nirmatrelvir; GC-376; compound 19;

   Abstract : Coronaviruses have caused three large outbreaks in the past century. The most recent one, also still ongoing, is represented by the SARS-CoV-2/Covid-19 pandemic. Efforts have been taken to develop efficient vaccines and antivirals and one of the major virus-based targets in drug development is represented by the main protease of these viruses. READ MORE

3. 2. Drug repositioning of protease inhibitors in combinational therapy as a treatment forCOVID-19

   University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Author : Max Malmberg; [2021]
   Keywords : COVID-19; protease inhibitor; combinational treatment;

   Abstract : There is currently no standardized treatment of COVID-19. Despite several vaccines being deployed, the need for an effective treatment in hospitalized patients is heavily sought after. READ MORE

4. 3. Neuroprotective effects of magnesium sulphate evaluated by fluoride resistant acid phosphatase, inorganic phosphate, lactate dehydrogenase and nitric oxide in rats with ischemia

   University essay from Uppsala universitet/Institutionen för kvinnors och barns hälsa

   Author : Maria Dorelis Montero Jimenez; [2020]
   Keywords : Biomarker; Magnesium; Neuroprotection; Respiratory arrest.;

   Abstract : Brain ischemia events are among the first three mortalities causes in the world associated with high treatments costs and in most cases some degree of permanent functional disability, thus it is necessary with new low cost and effective treatments. In the present study the potential neuroprotective effect of magnesium sulphate was evaluated by quantification of ischemic biomarkers: fluoride resistant acid phosphatase (FRAP), inorganic phosphate (Pi), lactate dehydrogenase (LDH) and nitric oxide (NO) in rats with global ischemia. READ MORE

5. 4. THE TRANSCRIPTIONAL LANDSCAPE OF B CELLS UPON MUCOSAL HEALING IN EXPERIMENTAL COLITIS : A SINGLE CELL TRANSCRIPTOMICS ANALYSIS

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Claudio Novella Rausell; [2020]
   Keywords : IBD; scRNA-seq; Machine Learning; Single Cell; Statistics; Dimensionality Reduction; UMAP;

   Abstract : Upon damage of the intestinal barrier, a complex interaction between the immune system and the epithelium is required to promote mucosal healing. However, which cell type and how the immune system orchestrates changes in the tissue transcriptomic landscape to eventually modulate mucosal healing is yet to be investigated. READ MORE

6. 5. Kinetic studies of carrier conjugated protease inhibitors

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Institutionen för kemi - BMC

   Author : Enrique Argenis López Olvera; [2019]
   Keywords : Proteases inhibitors; bioconjugates; enzyme kinetics; inhibition;

   Abstract : Conjugates of soybean trypsin inhibitor (SBTI) and potato serine protease inhibitor (PSPI) immobilized on metal oxide particles of ~100nm diameter were prepared. Inhibition of trypsin hydrolysis of BAPA by these conjugates was measured and enzyme kinetics constants kcat, KM, kcat/KM and ki were determined. READ MORE