Essays about: "down-staging"
Found 1 essay containing the word down-staging.
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1. Adjuvant and Down-Staging Treatment with Imatinib in Gastrointestinal Stromal Tumours
University essay from Hälsouniversitetets läkarutbildningAbstract : Background: GISTs are gastrointestinal mesenchymal tumours that express the type III receptor tyrosine kinase KIT. The KIT proto-oncogene encodes the receptor KIT. Most GISTs have gain-of-function mutations in the KIT or PDGFRA gene. The tyrosine kinase is therefore continuously activated leading to ligand-independent dimerization. READ MORE
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