Essays about: "down-staging"

Found 1 essay containing the word down-staging.

  1. 1. Adjuvant and Down-Staging Treatment with Imatinib in Gastrointestinal Stromal Tumours

    University essay from Hälsouniversitetets läkarutbildning

    Author : Anna Andersson; [2008]
    Keywords : GIST; imatinib; adjuvant; down-staging; neoadjuvant; mutation; KIT; PDGFRA;

    Abstract : Background: GISTs are gastrointestinal mesenchymal tumours that express the type III receptor tyrosine kinase KIT. The KIT proto-oncogene encodes the receptor KIT. Most GISTs have gain-of-function mutations in the KIT or PDGFRA gene. The tyrosine kinase is therefore continuously activated leading to ligand-independent dimerization. READ MORE