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Showing result 1 - 5 of 11 essays matching the above criteria.

  1. 1. Regulatory Driven Clustering of Single-Cell Data; Clustering of single-cell RNA sequencing from glioblastoma with a novel mathematical method

    University essay from Göteborgs universitet/Institutionen för matematiska vetenskaper

    Author : Kári Kristjánsson; [2023-08-08]
    Keywords : ;

    Abstract : Cancer is a leading cause of death worldwide. Single-cell RNA sequencing has arisen as an important method to explore the gene expression of biological cells, including cancer cells. In this study, we deployed a computational algorithm known as ScRegClust to dissect single-cell RNA-sequencing (scRNA-seq) data from brain tumors. READ MORE

  2. 2. Development and testing of in-house automatized spatial omics data analysis tool : NIPMAP (Niche-Phenotype Mapping)

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Raziyeh Mohseni; [2023]
    Keywords : ;

    Abstract : The functional and anatomical characteristics of cancer cells vary among patients. Additionally, therapeutic approaches display varying responses in different individuals and cancer types due to the anatomical and functional complexity of tumor. READ MORE

  3. 3. Computational prediction of cell-cell interactions in the brain-tumour microenvironment

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Paula Camargo Romera; [2023]
    Keywords : Cancer; Glioblastoma; Computational Biology; Bioinformatics; Microenvironment; Brain tumour; Interactions; Systems Biology;

    Abstract : Glioblastoma is the fastest-growing, and the most common malignant brain tumour in adults. It is normally treated with surgery and radio- or chemotherapy, but the approximate life expectancy is of 15 months with a high probability of cancer recurring. Therefore, there is a need for decreasing its severity. READ MORE

  4. 4. Characterization of the immunomicroenvironment of glioblastoma : Optimization of an antibody panel for detection of glioblastoma TME cells and effect of C3 on glioma cells.

    University essay from Malmö universitet/Fakulteten för hälsa och samhälle (HS)

    Author : Julia Wahldén; [2023]
    Keywords : Brain; cancer; glioblastoma; immune cells; immunofluorescence; tumor microenvironment; Cancer; glioblastom; immunceller; immunofluorescens; hjärnan; tumörmikromiljö;

    Abstract : Glioblastoma (GBM) is the most common primary brain tumor in adults and represents one of the most aggressive tumor types. Despite treatment GBM remains incurable and when treated the tumor recurs more aggressive and treatment resistant than before. READ MORE

  5. 5. Identification of Immunological Targets for Brain Cancer Immunotherapy

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Zhenda Wang; [2022]
    Keywords : Cancer immunotherapy; brain cancer; neoantigen; MHC HLA; TCR;

    Abstract : Background Cancer immunotherapy has yielded many successes. Yet to some hard-to-treat brain tumors, such as glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG), it still lacks substantial improvement. Neoantigens resulting from mutations in malignant cells are the key targets for employing adoptive cell therapies. READ MORE