Essays about: "gpcr"

Showing result 6 - 9 of 9 essays containing the word gpcr.

  1. 6. Computational Methods for the structural and dynamical understanding of GPCR-RAMP interactions

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Silvia Bahena; [2020]
    Keywords : Protein-protein interaction; coarse-grained; G protein-coupled receptors; receptor activity–modifying proteins;

    Abstract : Protein-protein interaction dominates all major biology processes in living cells. Recent studies suggestthat the surface expression and activity of G protein-coupled receptors (GPCRs), which are the largestfamily of receptors in human cells, can be modulated by receptor activity–modifying proteins (RAMPs). READ MORE

  3. 7. Development of a label-free biosensor method for the identification of sticky compounds which disturb GPCR-assays

    University essay from Institutionen för biologisk grundutbildning

    Author : Hamno Mohammed Kader; [2013]
    Keywords : Surface plasmon resonance SPR ; biosensor; Biacore; G-protein-coupled receptors GPCRs ; Low molecular weight LMW compounds; C-C chemokine receptor type 5 CCR5 ; acid-sensing ion channel 1a ASIC1a ; Thrombin; Carbonic Anhydrase II CA II ; P38α MAP kinase.;

    Abstract : It is widely known that early estimates about the binding properties of drug candidates are important in the drug discovery process. Surface plasmon resonance (SPR) biosensors have become a standard tool for characterizing interactions between a great variety of biomolecules and it offers a unique opportunity to study binding activity. READ MORE

  4. 8. Design, Synthesis and Biological testing of Novel ligands for Ghrelin Receptor

    University essay from Institutionen för vård och natur

    Author : Burri Harsha Vardhan Reddy; [2008]
    Keywords : Harsha; Burri; Reddy; skovde; sweden; denmark; Ghrelin;

    Abstract : Abstract G-protein coupled receptors (GPCRs) are having the high medical importance since almost half of the medicinal drugs are designed as modulators of receptor molecules. Crystal structure or NMR structures of GPCRs are very difficult to determine because all GPCRs are typically bound to the cell membrane and thus their molecular activation mechanism is still unclear. READ MORE

  5. 9. GPCR-Directed Libraries for High Throughput Screening

    University essay from Institutionen för kommunikation och information

    Author : Sagar Poudel; [2006]
    Keywords : ;

    Abstract : Guanine nucleotide binding protein (G-protein) coupled receptors (GPCRs), the largest receptor family, is enormously important for the pharmaceutical industry as they are the target of 50-60% of all existing medicines. Discovery of many new GPCR receptors by the “human genome project”, open up new opportunities for developing novel therapeutics. READ MORE