Essays about: "metabolomics"

Showing result 1 - 5 of 23 essays containing the word metabolomics.

  1. 1. Leveraging CNN for Automated Peak Picking in Untargeted Metabolomics without Parameter Dependencies

    University essay from Göteborgs universitet/Institutionen för data- och informationsteknik

    Author : Vivian Wang; Lidia Yalew; [2023-10-19]
    Keywords : Deep learning; Convolutional neural network; LC-MS; Peak Detection; Metabolomics; Faster R-CNN;

    Abstract : Metabolomics is a scientific discipline that involves the thorough analysis of small molecules, known as metabolites, found within a biological system. Furthermore, liquid chromatography-mass spectrometry (LC-MS) is a commonly used analytical technique in metabolomics for analysing biological samples due to its broad coverage of the measurable metabolome. READ MORE

  3. 2. Using metabolic profiles to screen for novel compounds in deep-sea sponges

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Samira Hilowle; [2022]
    Keywords : Metabolomics; Deep-sea sponges;

    Abstract : The chemical diversity of the phylum Porifera have provided marine natural products (MNPs) such as alkaloids, terpenoids and peptides with ranging biological activity. Every two days a novel compound deriving from sponges are discovered. READ MORE

  4. 3. Metabolomics database resolver

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Rajmund Csombordi; [2020]
    Keywords : metabolomics; metabolome compounds; metabolome substances; metabolome databases; pubchem; chebi; hmdb; lipidmaps; kegg compound;

    Abstract : Metabolomics is a rising field combining bioinformatics and cheminformatics together. A major component of research is having a reliable data source, which usually comes in the form of metabolomic databases. READ MORE

  5. 4. Optimization of a Methodology for Cell Based Untargeted Metabolomics with UHPLC-Q-ToF-MS

    University essay from Uppsala universitet/Analytisk farmaceutisk kemi

    Author : Jens Westerinen; [2020]
    Keywords : ;

    Abstract : Metabolomics is the study of small molecules (molecular weight < 1500 Da) in a biological system and can provide relevant information about endpoints of biochemical pathways by establishing metabolic profiles for different sample cohorts and comparing these through multivariate data analysis. The aim of this thesis was to establish and test a suitable methodology for cell-based untargeted metabolomics, utilizing UHPLC-MS. READ MORE

  6. 5. Predicting Mechanisms of Toxicity for Drug Development

    University essay from Göteborgs universitet/Institutionen för data- och informationsteknik

    Author : SÖREN RICHARD STAHLSCHMIDT; [2019-10-04]
    Keywords : Predictive Toxicology; Metabolomics; Semi-Supervised Learning; DoseResponse;

    Abstract : The aim of this thesis is to predict different mechanisms of toxicity from the metabolomic response of HepG2 liver cells. In order to utilize the metabolomic data the a semisupervised machine learning approach is investigated, namely the cluster-then-label approach. READ MORE