Essays about: "inter-individual variability"

Found 5 essays containing the words inter-individual variability.

  1. 1. Automatic Development of Pharmacokinetic Structural Models

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Alzahra Hamdan; [2022]
    Keywords : pharmacometrics; non-linear mixed effects; modelling; pharmacokinetics; NONMEM; automation; exhaustive algorithm; stepwise algorithm; structural models; inter-individual variability; residual error models; model selection;

    Abstract : Introduction: The current development strategy of population pharmacokinetic models is a complex and iterative process that is manually performed by modellers. Such a strategy is time-demanding, subjective, and dependent on the modellers’ experience. READ MORE

  3. 2. Evaluation of Robust Model Building Tools to Improve the Efficiency of Non-linear Mixed Effect Model Building Workflows

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Karin Norgren; [2021]
    Keywords : Population PK modeling; Pharmacometrics; NLME modeling;

    Abstract : Population PK models aim to describe the change in drug concentration over time for a specific population. The populations in population PK modelling often refer to subjects in a clinical trial of a potential drug candidate. READ MORE

  4. 3. Thermo-effector responses to a 5-day high-intensity cold-acclimation procedure

    University essay from KTH/Omgivningsfysiologi

    Author : Frederick Wilkins; [2020]
    Keywords : Hypothermia Acclimation procedure thermo effector response;

    Abstract : Long-term, repeated exposures to cold might lead to cold adaptation. The study examined, in a small homogeneous group of non-acclimatised men, the inter-individual response to a short-term, high-intensity cold acclimation regimen. READ MORE

  5. 4. Heart rate variability for driver sleepiness assessment

    University essay from Linköpings universitet/Institutionen för medicinsk teknik

    Author : Anna Persson; [2019]
    Keywords : Heart rate variability; sleepiness; drowsiness; fatigue; driver sleepiness; Hjärtfrekvensvariabilitet; sömnighet; trötthet; bilförare;

    Abstract : Studies have reported that around 20 % of all traffic accidents are caused by a sleepy driver. Sleepy driving has been compared to drunk driving. A sleepy driver is also an issue in the case of automated vehicles in the future. Handing back the control of the vehicle to a sleepy driver is a serious risk. READ MORE

  6. 5. Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Cyclosporine A in Whole Blood

    University essay from Institutionen för kemi

    Author : Ann-Sofie Jonsson; [2009]
    Keywords : ;

    Abstract : Cyklosporin A (CsA) är en cyklisk polypeptid med molekylvikten är 1202.6 Da. Substansen har svampursprung (Tolypocladium inflatum Gams) och starka immunhämmande egenskaper. READ MORE