Essays about: "polysorbate 80"

Found 5 essays containing the words polysorbate 80.

1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

   University essay from Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

   Author : Elina Edidovica; [2024]
   Keywords : Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

   Abstract : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. READ MORE

3. 2. Evaluation of different block-copolymer coatings of iron oxide nanoparticles by flash nanoprecipitation

   University essay from KTH/Fiber- och polymerteknologi

   Author : Felix Bogdan; [2023]
   Keywords : Nanopartiklar; organisk katalysator; ROP; block-sampolymerer PL G A; oljesyra IONPs; Nanoparticles; organic catalyst; ROP; block-copolymers PL G A; oleic acid IONPs;

   Abstract : Nanopartiklar (NP) erbjuder unika möjligheter för medicinska tillämpningar, inklusive kontrollerad frisättning av cancerläkemedel, användning som bildkontrast vid avbildningsprocedurer eller hypertermisk behandling av cancerceller. Flash nanoprecipitation (FNP) producerar NPs för att kombinera dessa tillämpningar i en snabb, billig och skalbar beläggningsprocess. READ MORE

4. 3. Study of surfactant-preservative and protein-preservative interactions in multi-dose injectable formulation

   University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

   Author : Javier Lagares Martín; [2023]
   Keywords : Phenol; polysorbate 80; cloud point; somatropin; aggregation; titration; light scattering; salt; surfactant; preservative; protein; tonicity adjusting agents; multi-dose injectable formulation; pharmaceutical technology; Technology and Engineering;

   Abstract : Multidose injectable formulations require a preservative such as phenol to ensure sterility and protection against microbial contamination during clinical use. However, it is known that the interaction between these components and non-ionic surfactants such as polysorbate 80, also found in this type of formulations, present incompatibilities, which can lead to decreases in the efficacy of the product. READ MORE

5. 4. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation

   University essay from Lunds universitet/Kemiteknik (CI)

   Author : Owais Khalil; [2023]
   Keywords : Sponge phase; lipid nanoparticles; microfluidics; SAXS; cryo-TEM; DLS; chemical engineering; Chemistry;

   Abstract : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. READ MORE

6. 5. Effects of pharmaceutical excipients on the chemical stability of therapeutic proteins in a parenteral formulation

   University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

   Author : Emmanuel Gulangayan Deniola; [2022]
   Keywords : Chemical stability; protein degradation; GA-Z; somatropin; pharmaceutical excipients; liquid chromatography; pharmaceutical technology; Chemistry;

   Abstract : Proteins and peptides are widely used for the prevention, management, and cure of various illnesses. This vast therapeutic potential represents a significant portion of the pharmaceutical industry in the form of vaccines, antibodies, enzymes, and other protein-based therapeutics. READ MORE