Essays about: "Activity Profiling"

Showing result 1 - 5 of 15 essays containing the words Activity Profiling.

1. 1. Combining Cell Painting, Gene Expression and Structure-Activity Data for Mechanism of Action Prediction

   University essay from Uppsala universitet/Nationellt resurscentrum för biologi och bioteknik

   Author : Erik Everett Palm; [2023]
   Keywords : bioinformatics; deep learning; machine learning; joint model; tabular data; image data;

   Abstract : The rapid progress in high-throughput omics methods and high-resolution morphological profiling, coupled with the significant advances in machine learning (ML) and deep learning (DL), has opened new avenues for tackling the notoriously difficult problem of predicting the Mechanism of Action (MoA) for a drug of clinical interest. Understanding a drug's MoA can enrich our knowledge of its biological activity, shed light on potential side effects, and serve as a predictor of clinical success. READ MORE

3. 2. Characterization of ulvan polysaccharide degrading enzymes from Wenyingzhuangia fucanilytica

   University essay from Lunds universitet/Bioteknik; Lunds universitet/Bioteknik (master)

   Author : Erik Apelqvist; [2022]
   Keywords : Enzyme; Enzymatic characterization; Recombinant protein producaiton; Protien purification; E. coli; W. fucanilytica; Transformation; Overexpression; Seaweed; Ulvan; Polysaccharides; biotechnology; Biology and Life Sciences;

   Abstract : The aim of this thesis was to fully characterize the enzyme WFp-105, including bioinformatic analysis, structural modeling, full activity and stability characterization and product determination. As well as for the enzyme WFp-37; optimize protein production in regard to expression strains and cultivation temperature, analyzing the genomic context as well as performing an initial activity detection. READ MORE

4. 3. Using metabolic profiles to screen for novel compounds in deep-sea sponges

   University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Author : Samira Hilowle; [2022]
   Keywords : Metabolomics; Deep-sea sponges;

   Abstract : The chemical diversity of the phylum Porifera have provided marine natural products (MNPs) such as alkaloids, terpenoids and peptides with ranging biological activity. Every two days a novel compound deriving from sponges are discovered. READ MORE

5. 4. Privacy and user profiling : Profile-based evaluation of what different third party services may learn about a user

   University essay from Linköpings universitet/Institutionen för datavetenskap

   Author : Isabell Öknegård Enavall; Julia Mineur; [2021]
   Keywords : third parties; privacy; network security; user modeling;

   Abstract : Online behavioural targeted advertising has become a leading method to increase theeffectiveness of advertisement online. The advertisement is based on information aboutusers’ internet activities collected by third party tracking services. READ MORE

6. 5. Epigenetic and transcriptional effects of full-length LINE-1 retrotransposons in human neural progenitor cells

   University essay from Lunds universitet/Examensarbeten i bioinformatik

   Author : Ninoslav Pandiloski; [2021]
   Keywords : Biology and Life Sciences;

   Abstract : Transposable elements (TE) are parasitic genetic entities that have the ability to alter their position within a genome and have the potential to influence its functionality. Although TEs play beneficial roles in the evolution of their host, they are active in various human disorders including neurological diseases, where may contribute to the progress of the disease. READ MORE