Essays about: "Deoxyribonucleoside kinases"

Found 2 essays containing the words Deoxyribonucleoside kinases.

1. 1. Cloning, Expression and Purification of a Mutant Tomato Thymidine Kinase 1 for Crystallography

   University essay from Lunds universitet/Tillämpad biokemi

   Author : Mohamad Nesrini; [2015]
   Keywords : protein expression; protein engineering; Azidothymidine; thymidine kinase; deoxyribonucleoside kinases; nucleosides; nucleoside analog; suicide gene therapy; tillämpad biokemi; applied biochemistry; BEVS.; Technology and Engineering; Chemistry;

   Abstract : Thymidine kinase 1 from tomato (ToTK1) is a newly discovered deoxyribonucleoside kinase (dNK) that has been subject to study due to its in vitro and in vivo properties making it an interesting suicide gene candidate for the treatment of brain tumors. The ToTK1 phosphorylates the nucleoside analogue 3-azido-2,3-dideoxythymidine (azidothymidine, AZT) equally well as its natural substrate thymidine (dThd). READ MORE

3. 2. Detection of Thymidine Kinase 1 Activity in Whole Blood Using an Oligonucleotide System

   University essay from

   Author : Heba Abdelfatah Possnert; [2014]
   Keywords : Deoxyribonucleoside kinases; cell proliferation markers; salvage pathway; hematological malignancies; therapy monitoring;

   Abstract : In today’s medical science studies, many tumor markers are being used to monitor cancer cell proliferation, but the number of assays for analysis of these markers are few. The aim of this study was to find an easier and more time-efficient way to measure the activity of a specific tumor marker called tymidine kinase 1 (TK1). READ MORE