Essays about: "Direct coupling analysis DCA"
Found 4 essays containing the words Direct coupling analysis DCA.
-
1. Co-evolutional anaylsis of the Na+,K+-ATPase’s β-subunit dimerization
University essay from KTH/Tillämpad fysikAbstract : Does the active membrane transporter, Na+,K+-ATPase dimerize? If it does, whatis the functional benefit? Does it increase or decrease the turnover rate? Theseare still unanswered questions and current research topics. Previous studies havedemonstrated dimerizations in closely related proteins of the P-type ATPase family. READ MORE
-
2. Beyond high mutation highrecombination limit in statisticalgenetics
University essay from KTH/FysikAbstract : One considers the bi-allelic model in population genetics which describes a population of genomes evolving under the processes of selection, mutation, recombination and drift. A focus is made on the Quasi-Linkage Equilibrium (QLE) phase with recent derivations from Neher and Shraiman, which exists for fast recombinations compared to selection strength and whose dynamics is greatly simplified compared to the general case. READ MORE
-
3. Sequence Correlations in HP Model Proteins
University essay from Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisationAbstract : Amino acids that are in close contact in a protein structure tend to co-evolve, which gives rise to sequence correlations. Direct coupling analysis (DCA) is a method for predicting such contacts directly from sequence correlations, without assuming any prior knowledge of structures. READ MORE
-
4. Testing Direct Coupling Analysis on HP Model Proteins
University essay from Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisationAbstract : Direct coupling analysis (DCA) models correlations in sets of related (homologous) protein sequences using a Potts-like spin model ansatz. From the couplings of the Potts model, derived by inverse statistical mechanics, residue-pair contacts in the 3D structure of the protein are predicted. READ MORE