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Found 4 essays matching the above criteria.

  1. 1. Fluorescent molecules as probes for characterization of amyloid β fibrils

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Denisse Marginean; Ebba Hellstrand; [2021]
    Keywords : Alzheimer s disease; amyloid beta; amyloid; fluorescent probes; fluorescent ligands;

    Abstract : Alzheimer’s Disease (AD) is the leading cause of dementia in the world and the World Health Organization has recognized AD as a global public health priority. One of the pathological hallmarks of AD is amyloid plaques formed from amyloid β (Aβ) fibrils. Aβ is formed when amyloid precursor protein is cleaved by secretase enzymes. READ MORE

  3. 2. Characterization of the fusion protein mNG-Aβ1-42 as a fluorescence reporter probe for amyloid structure

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Linnéa Fredén; [2020]
    Keywords : Alzheimer’s Disease AD ; Amyloids; Aβ; fusion protein; mNeonGreen; mNG-Aβ1-42; Crystallization; mouse brain tissue; human brain tissue; amyloid fluorescent probes;

    Abstract : Alzheimer’s Disease, also called AD, is a horrible, degenerative brain disease that more than 35 million people over the world have. Today, there is no cure for this disease, only treatments that are temporarily relieving the symptoms. The two proteins that is thought to be the main cause of AD is amyloid β (Aβ) and tau. READ MORE

  4. 3. A method for unbiased analysis of fluorescence microscope images of Alzheimer’s disease related amyloids

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Samuel Haglund; [2020]
    Keywords : Amyloid beta; Luminocent conjugated oligothiophene; Hyperspectral image analysis; Alzheimers disease;

    Abstract : Alzheimer's disease is a widespread disease that has devastating effects on the human brain and mind. Ultimately, it leads to death and there are currently no treatment methods available that can stop the disease progression. READ MORE

  5. 4. Fluorescent fusion proteins as probes to characterize tau fibril polymorphism

    University essay from Linköpings universitet/Kemi

    Author : Max Lindberg; [2019]
    Keywords : Alzheimer’s disease AD ; amyloids; FRET; tau; MAPT; fibrillation kinetics; seeding; fusion protein; EGFP; ECFP; EYFP; ThT; X-34; BTD14;

    Abstract : Alzheimer's disease (AD) is a large and growing problem and while we today lack a full understanding of this disease, we know that the protein tau and the amyloid fibrils it forms play a central role in its development. We also know that these fibrils can have different morphologies in different diseases and that fibrils produced in vitro not necessarily adopt any of the morphologies found in patients. READ MORE