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Showing result 1 - 5 of 16 essays matching the above criteria.

  1. 1. Ligand-stimulated cleavage of PDGFR-beta

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Agni Karolina Tsiatsiou; [2023]
    Keywords : ;

    Abstract : Platelet-derived growth factor receptors (α and β) are included in the family of receptor tyrosine kinases (RTKs). The dimeric PDGF ligands bind to the PDGF receptors and this results in receptor dimerization, autophosphorylation, and thus activation. The autophosphorylated receptor dimer activates numerous signaling pathways. READ MORE

  3. 2. Influence of Nrf2 Activators and Keap1 Inhibitors on Antioxidative Phenotypes of THP-1-Derived M1 and M2 macrophages: Therapeutic Potential for Systemic Lupus Erythematosus

    University essay from Uppsala universitet/Institutionen för immunologi, genetik och patologi

    Author : Leo Svahn; [2023]
    Keywords : NRF2; KEAP1; THP-1; M1; M2; SLE;

    Abstract : POPULAR SCIENTIFIC SUMMARY Systemic lupus erythematosus (SLE) is not your average disorder. It behaves like a mischievous troublemaker, wreaking havoc throughout the body, causing inflammation that affects multiple organs. READ MORE

  4. 3. The GSK-3 inhibitor has no effect on production of IL-1β in LPS- and Nigericin-stimulated THP-1 macrophages

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Jessica Halan Söderberg; [2022]
    Keywords : ;

    Abstract : Inflammation is the body's natural defense reaction and is known since ancient times. The inflammation is divided into two main phases, acute and chronic inflammation dependent on the process and cellular mechanisms of the inflammation. READ MORE

  5. 4. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus

    University essay from Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Author : Elin Öberg; [2022]
    Keywords : x-ray crystallography; protein crystallization; Venezuelan equine encephalitis virus; structure-based drug design; applied biochemistry; Technology and Engineering;

    Abstract : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. READ MORE

  6. 5. Association of ACE and PAI-1 gene polymorphisms with clinical outcomes of obstructive sleep apnea

    University essay from Högskolan i Skövde/Institutionen för hälsovetenskaper

    Author : Ruta Mickeviciute; [2021]
    Keywords : ;

    Abstract : Obstructive sleep apnoea (OSA) is a sleeping disorder leading to complications such as daytime-sleepiness, migraines and snoring and is often associated with coronary artery disease (CAD). Studies have suggested the contribution of genetic factors in aetiology of OSA. READ MORE