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Showing result 1 - 5 of 12 essays matching the above criteria.

  1. 1. Metabolic Crisis Induced by Antiepileptic Drugs in Patients with Mitochondrial Epilepsy : The Effect of Valproic Acid, Topiramate and Propofol on Mitochondrial Function

    University essay from Malmö universitet/Institutionen för biomedicinsk vetenskap (BMV)

    Author : Angelica Dahlgren; [2023]
    Keywords : ATP; epilepsy; mitochondria; oxygen consumption; propofol; topiramate; valproic acid;

    Abstract : Mitochondria are important cytosolic organelles present in nearly all eukaryotic cells. The main function of mitochondria are to generate the vast majority of ATP through the process of oxidative phosphorylation. READ MORE

  3. 2. Towards individualised anaesthesia: A comparison between target-controlled infusion and closed-loop control

    University essay from Lunds universitet/Institutionen för reglerteknik

    Author : Amanda Gustafsson; [2023]
    Keywords : Technology and Engineering;

    Abstract : Individualised healthcare is the future of medicine, due to the so called inter-patient variability. The inter-patient variability involves differences in the drug response between different patients. The effect of a drug can usually be divided into pharmacokinetics (PK) and pharmacodynamics (PD). READ MORE

  4. 3. Identifiability of pharmacological models from data

    University essay from Lunds universitet/Institutionen för reglerteknik

    Author : Amina Gojak; [2021]
    Keywords : Technology and Engineering;

    Abstract : In order to automate anaesthesia in patients using propofol, closed-loop control systems with models that describe the time course of the drug effects on the body are required, usually being represented by pharmacokinetics and pharmacodynamics(PKPD). This thesis focused on evaluating parameter identifiability for the PK part of the model, using a model proposed by Eleveld et al. READ MORE

  5. 4. Narkotikaklassade läkemedel och propofol : rutiner för förvaring och hantering inom djursjukvården, samt dess följsamhet

    University essay from SLU/Dept. of Clinical Sciences

    Author : Jeanette Andersson; Linnéa Edselius; [2020]
    Keywords : narkotikaklassade läkemedel; propofol; opioider; förvaring; veterinärmedicin; lagar; föreskrifter; djurklinik; djursjukhus; följsamhet; missbruk; stöld; läkemedelslagar; djuromvårdnad;

    Abstract : Syftet med detta kandidatarbete var att undersöka hur lagar och föreskrifter för hantering och förvaring av narkotikaklassade läkemedel och propofol ser ut och hur dessa efterföljs på svenska djurkliniker. Målet var att granska den kliniska verksamhetens rutiner för förvaring, journalföring, uppföljning samt dess följsamhet. READ MORE

  6. 5. Computational Modeling and Characterization of the Human Tri-Heteromeric GABAA Receptor

    University essay from KTH/Tillämpad fysik

    Author : Michael Luxemburg; [2019]
    Keywords : ;

    Abstract : -aminobutyric acid receptors of type A (GABAARs) are the majorinhibitory neurotransmitter receptors in the human brain, andare modulated by a vast range of exogenous molecules, such assedatives and anesthetics. In the last year, the first cryo-electronmicroscopy (cryo-EM) images of the closed and desensitized statesof the GABAAR were released, enabling fruitful research throughsimulations of these complex proteins. READ MORE