Essays about: "surface protein"

Showing result 21 - 25 of 154 essays containing the words surface protein.

  1. 21. Development of an Affibody-based Prodrug Against HER2 for Cancer Therapy

    University essay from KTH/Proteinvetenskap

    Author : Cornelia Westerberg; [2021]
    Keywords : Affibody; therapeutic protein; prodrug; affibody-based prodrug; HER2-targeted therapy;

    Abstract : Affinity proteins constitute an important category of cancer therapeutics. Owing to properties such as high target affinity and selectivity, therapeutic proteins offer more targeted therapy than small molecule drugs. The target molecules are typically proteins that are overexpressed on the surface of tumour cells, such as membrane-bound receptors. READ MORE

  3. 22. Affinity Based Capture of Circulating Tumour Cells Using Designed Ankyrin Repeat Proteins (DARPins) in a Microfluidic System

    University essay from KTH/Proteinvetenskap

    Author : Emil Spåre; [2021]
    Keywords : Designed ankyrin repeat proteins; DARPins; microfluidics; circulating tumour cells; affinity based cell capture; surface modification; Designade ankyrinupprepningsproteiner; DARPiner; mikrofluidik; cirkulerande tumörceller; affinitetsbaserad celluppfångst; ytförändring;

    Abstract : Designade ankyrinupprepningsproteiner (DARPiner) är små, mycket stabila antikroppsmimetiska proteiner. I det här projektet användes anti-EpCAM-DARPiner tillsammans med mikrofluidik för att avgära om de kunde fånga upp HCT116-celler mer effektivt än anti-EpCAM-antikroppar. READ MORE

  4. 23. Production and Evaluation of a Bombesin Analogue Conjugated to the Albumin-Binding Domain and DOTA for Prostate Cancer Radiotherapy

    University essay from KTH/Proteinvetenskap

    Author : Fredrika Landmark; [2021]
    Keywords : bombesin; prostate cancer; radiotherapy; human serum albumin; half-life extension; bombesin; prostatacancer; radioterapi; humant serumalbumin; halveringstidsförlängning;

    Abstract : Prostate cancer is one of the most common types of cancer worldwide and claims hundreds of thousands of lives annually. Currently the most common treatment for prostate cancer is external beam radiotherapy, however, this treatment comes with serious side effects since it lacks selectivity for the cancer cells. READ MORE

  5. 24. Biophysical characterization of and screening for binders and potentiator compounds that modulate the binding of PDZ domains to the C-terminal peptide motifs of target proteins

    University essay from KTH/Proteinvetenskap

    Author : Carl Olsson; [2021]
    Keywords : Post synaptic density protein 95; PDZ-domains; N-methyl-D-aspartate receptor; NMDAR hypofunctional hypothesis; GluN2b; Differential scanning fluorimetry; Surface plasmon resonance; Fragment based drug design; Assay development;

    Abstract : The N-methyl-D-aspartate receptor (NMDAR) hypofunctional hypothesis is believed to explain one of the contributing factors to schizophrenia. This hypothesis suggests the dysregulation of NMDAR, a protein responsible for receiving signals from the synapses between neurons, is the cause of some of the symptoms seen in schizophrenia. READ MORE

  6. 25. Sequence Diversity andAntibody Response to Autologous and Heterologous MSP2 Antigens in a Prospective Malaria Immunology Cohort

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Julia Zerebinski; [2021]
    Keywords : Malaria; sub-Saharan Africa; merozoite surface protein; antibody; immune response; antigen target;

    Abstract : Malaria, caused by the Plasmodium parasite and transmitted by mosquitoes, kills almost half a million people each year. Drug resistance in both the parasite and its vector make preventative measures increasingly important, and a fully protective vaccine is absolutely necessary to eradicate the disease. READ MORE