Essays about: "therapeutic protein"

Showing result 1 - 5 of 72 essays containing the words therapeutic protein.

  1. 1. Effects of phosphorylation on the ADP-ribosylation activity of PARP16

    University essay from Lunds universitet/Kemiska institutionen

    Author : Virginia Martín Cristóbal; [2023]
    Keywords : ADP-ribosylation; Kinases; PARP16; Phosphorylation; UPR biochemistry; Biochemistry; Chemistry;

    Abstract : PARP16/ARTD15 is an intracellular mono-ADP-ribosyltransferase that catalyzes auto- and heteromodification by transfer of a single ADP-ribose moiety. It belongs to the ADP-ribosyltransferase (ART) superfamily. READ MORE

  3. 2. Assessment and evaluation of heterogeneity in data from immune infiltration spatial niches in lung cancer

    University essay from Lunds universitet/Matematisk statistik

    Author : Mahta Keivani Najafabadi; [2023]
    Keywords : Mathematics and Statistics;

    Abstract : The protein biomarker expressions in three types of sampled immune INFILTration spatial niches in lung cancer tissue were measured using the new technology Digital Spatial Profiler (DSP). The three types of immune INFILTration that were observed in lung tumors were STROMA identified as immune cells separate from tumor cells, Tertiary lymphoid structures (TLS) identified as dense structures of organized immune cells and finally Infiltraterate where immune cells dispersed among and in direct contact with tumor cells (INFILT). READ MORE

  4. 3. Intersecting Graph Representation Learning and Cell Profiling : A Novel Approach to Analyzing Complex Biomedical Data

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Nima Chamyani; [2023]
    Keywords : Graph representation learning; Cell profiling; Biological systems; Network medicine; Graphs; Machine learning techniques; Graph neural networks GNNs ; Protein-Compound-Pathway interactions; Biomarkers; Drug discovery;

    Abstract : In recent biomedical research, graph representation learning and cell profiling techniques have emerged as transformative tools for analyzing high-dimensional biological data. The integration of these methods, as investigated in this study, has facilitated an enhanced understanding of complex biological systems, consequently improving drug discovery. READ MORE

  5. 4. Investigations of miR-34a structure and dynamics by SHAPE MaP and optimal time between transfection and modification by qPCR

    University essay from KTH/Proteinvetenskap

    Author : Ellinor Lindén; [2023]
    Keywords : SHAPE MaP; qPCR; miRNA; HNF4α; mRNA-34a; SHAPE MaP; qPCR; miRNA; HNF4α; mRNA-34a;

    Abstract : microRNA (miRNA) är korta icke-kodande RNA sekvenser som har fått ökande uppmärksamhet då de kan binda till mRNA och styra vårt genuttryck. Omkring trettio procent av våra proteinkodande gener styrs av miRNA. miRNA binder till mRNA vilket hindrar dess translation eller leder till nedbrytning av mRNA. READ MORE

  6. 5. Molecular mapping of the HGSOC tumour microenvironment

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Philippine Louail; [2023]
    Keywords : Immunology; Ovarian cancer; Multiplex Immunofluorescence; scRNA sequencing; Bioinformatics; Image analysis;

    Abstract : High-grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer, and its heterogeneity poses a challenge for the discovery of reliable diagnostic biomarkers, therapeutic targets, and predicting treatment response, particularly to immunotherapy. The current standard diagnostic and treatment options are inadequate, resulting in late diagnosis and poor prognosis. READ MORE