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Showing result 1 - 5 of 24 essays matching the above criteria.
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1. A Machine Learning Approach on Analysis of Emission Spectra for Application in XFEL Experiments
University essay from Uppsala universitet/Institutionen för fysik och astronomiAbstract : In this thesis we investigate two potential applications of machine learning in the context of X-ray imaging and spectroscopy of biological samples, particularly such using X-ray free electron lasers (XFEL). We first investigate the possibility of using an emission spectrum, recorded from a sample after being probed by an incident X-ray, as a diagnostic tool. READ MORE
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2. Acoustic Focusing of Lysozyme Crystals
University essay from KTH/Tillämpad fysikAbstract : Acoustic focusing of microscale protein crystals with acoustophoresis technology could reduce clogs during experiments with the scientific technique serial femtosecond x-ray crystallography (SFX). SFX determines molecular structures of proteins, these structures are valuable in drug discovery and fundamental biomedical research. READ MORE
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3. Expression and purification of pyruvate transporting human mitochondrial pyruvate carrier (MPC) protein complex for structural studies
University essay from Lunds universitet/Examensarbeten i molekylärbiologiAbstract : Pyruvate is one of the main molecules needed for the citric acid cycle, which produces energy in the form of ATP. The citric acid cycle reaction occurs in the mitochondrial matrix, and for pyruvate to participate in the reaction, it needs to be transported from the cytosol across the mitochondrial membranes into the mitochondrial matrix. READ MORE
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4. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus
University essay from Lunds universitet/Tillämpad biokemi; Lunds universitet/BeräkningskemiAbstract : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. READ MORE
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5. Investigation of the function of the SH3-like domain of the Saccharopolyspora erythraea iron-dependent regulator
University essay from Uppsala universitet/Institutionen för kemi - BMCAbstract : The bacterium Saccharopolyspora erythraea is utilized to produce the widely used antibiotic erythromycin. With the increasing problem of antibiotic resistance, the development of derivatives of the drug is of great importance. To produce antibiotics biosynthetically, it is crucial to understand the metabolic pathways utilized by the bacterium. READ MORE
