Essays about: "Biopharmaceuticals"

Showing result 1 - 5 of 12 essays containing the word Biopharmaceuticals.

  1. 1. Comparison of Lectins and their suitability in Lectin Affinity Chromatography for isolation of Glycoproteins

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Pontus Andersson; [2020]
    Keywords : biotechnology; lectins; chromatography; glycoproteins; lectin affinity chromatography; LAC; ConA; Concanavalin A; bioteknik; lektiner; kromatografi; affinitetskromatografi; glykoproteiner; ConA; Concanavalin A;

    Abstract : Virtually all extracellular proteins in humans are glycoproteins and likewise are many biopharmaceuticals. The glycosylation is directly correlated to biological function and stability of these proteins. The ability to isolate glycoproteins is thus of great importance in many applications. READ MORE

  2. 2. The art of making a comprehensive stability study

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Roman Lord; [2020]
    Keywords : Biopharmaceuticals; mAbs; SEC; stability study design; technical analytical chemistry; teknisk analytisk kemi; Technology and Engineering; Chemistry;

    Abstract : There is a need for harmonisation of stability study designs of monoclonal antibodies. Monoclonal antibodies (mAbs) are widely used in treatments for various diseases. Like all drugs, their quality must be verified through stability studies. READ MORE

  3. 3. Selection and characterization of bispecific ADAPT molecules for enhanced biodistribution in cancer therapy

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Jesper Borin; [2020]
    Keywords : ABD; ADAPT; HER2; CEACAM6; HSA; Phage display; Cancer therapy; Spatial bispecificity; Half-life extension; Biodistribution;

    Abstract : Established biopharmaceuticals such as antibodies and derivatives thereof are relatively large. In cancer therapy, this creates a steep drug concentration gradient within tumors, leaving cells far from blood vessels effectively untreated. READ MORE

  4. 4. Construction of a fusion protein for anchoring the inflammatory receptor NLRP3 to the cell membrane

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Rebecca Ling; [2019]
    Keywords : NLRP3 inflammasome; Overlap PCR; Fusion Protein; LPI™ technology;

    Abstract : The innate immune system are a cooperation of many components – receptors being one of them. Both membrane-bound and cytosolic receptors play a large role in the defence system against pathogens and danger. READ MORE

  5. 5. Increased expression of therapeutic proteins by identification of 3'-UTRs from high expressing genes in CHO cells

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Alexander Westlund; [2019]
    Keywords : Mammalian cell; CHO; E. coli; protein expression; plasmid; transformation; Fc-fusion protein; flow cytometry; FACS; transfection; mRNA; UTR; gene engineering;

    Abstract : Therapeutic proteins, a.k.a. biopharmaceuticals, are most commonly produced in expression systems derived from Chinese Hamstery Ovary (CHO) cells, thanks to great capacity of post-translational modifications like secretation, folding and glycosylation. READ MORE