Essays about: "Cancer mutations"

Showing result 16 - 20 of 50 essays containing the words Cancer mutations.

1. 16. Expression of the Sloppymerase™ in NIH/3T3 Cells: Exploring the Versatility of an Error Prone Fusion Polymerase

   University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Author : Mikaela Mattsson; [2021]
   Keywords : ;

   Abstract : The aim of this project is to assess the versatility of the Sloppymerase by performing stable transfection in NIH/3T3 cells and decide whether this cell line can be a candidate for further research on the Sloppymerase as a cancer model. The American cancer society predicts 1,806,590 new cancer cases in the US in 2020. READ MORE

3. 17. Segmentation and Prediction of Mutation Status of Malignant Melanoma Whole-slide Images using Deep Learning

   University essay from Lunds universitet/Avdelningen för Biomedicinsk teknik

   Author : Elin Johansson; Fanny Månefjord; [2021]
   Keywords : deep learning; image analysis; malignant melanoma; tissue segmentation; mutation classification; Inception v3; Technology and Engineering;

   Abstract : Malignant melanoma is an aggressive type of skin cancer. Gene mutations can make the disease progress faster, but specialised treatment exists. Today, gene mutations are detected with DNA-analysis which is costly and time-consuming. READ MORE

4. 18. Interactions between Rho-ROCK signaling and the tumor microenvironment in neuroblastoma

   University essay from Uppsala universitet/Mikrobiologi och immunologi; Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Adena Pepich; [2021]
   Keywords : cancer and oncology; pediatric cancer; neuroblastoma; rho ROCK signaling; rho-associated kinases; tumor microenvironment; cytotoxic T cells; neuroblastom; pediatrik onkologi; rho-kinaser;

   Abstract : Neuroblastoma is a childhood cancer of the peripheral sympathetic nervous system, emerging from cells of the neural crest. In Sweden, neuroblastoma accounts for 20 cases out of all, 300-350, pediatric cancer cases each year (Barncancerfonden 2019, Turup on behalf of Cancer Centrum 2019). READ MORE

5. 19. Non-coding constraint mutations impact the gene regulatory system in osteosarcoma

   University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi; Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Raphaela Pensch; [2021]
   Keywords : cancer; osteosarcoma; cancer genomics; evolutionary constraint; non-coding mutations; gene regulation;

   Abstract : The non-coding space makes up around 98 % of the genome, but cancer-driving mutations have so far mostly been discovered in protein-coding regions. The majority of somatic non-coding mutations are neutral passenger mutations and identifying non-coding mutations with driving roles in cancer poses a challenge. READ MORE

6. 20. Exploring connectivity patterns in cancer proteins with machine learning

   University essay from KTH/Skolan för elektroteknik och datavetenskap (EECS)

   Author : Knut-Rasmus Bergendal; [2021]
   Keywords : Self-Organizing map; machine learning; Protein conformation; Cancer mutations; självorganiserande karta; maskininlärning; Proteinstruktur; Cancermutationer;

   Abstract : Proteins are among the most versatile organic macromolecules essential for living systems and present in almost all biological processes. Cancer is associated with mutations that either enhance or disrupt the conformation of proteins. These mutations have been shown to accumulate in specific regions of a proteins three dimensional structure. READ MORE