Essays about: "cancer genomics"

Showing result 1 - 5 of 7 essays containing the words cancer genomics.

  1. 1. Regulatory Driven Clustering of Single-Cell Data; Clustering of single-cell RNA sequencing from glioblastoma with a novel mathematical method

    University essay from Göteborgs universitet/Institutionen för matematiska vetenskaper

    Author : Kári Kristjánsson; [2023-08-08]
    Keywords : ;

    Abstract : Cancer is a leading cause of death worldwide. Single-cell RNA sequencing has arisen as an important method to explore the gene expression of biological cells, including cancer cells. In this study, we deployed a computational algorithm known as ScRegClust to dissect single-cell RNA-sequencing (scRNA-seq) data from brain tumors. READ MORE

  3. 2. Investigation of Chromatin Organization and mRNA Expression in Drug Treated Human Erythroleukemia Cells

    University essay from KTH/Proteinvetenskap

    Author : Anam Minhas; [2022]
    Keywords : Erythroleukemia cells; mRNA-seq; ATAC-seq; Doxorubicin; Vinblastine; Erytroleukemiceller; mRNA-expression; kromatin; Doxorubicin; Vinblastine;

    Abstract : Syftet med detta projekt var att undersöka hur vanligt använda cancerläkemedel påverkar mRNA-uttryck och kromatinorganisation i humana erytroleukemiceller. Som modell användes K562-celler från en patient i blastocystkris (2), för att utvärdera leukemicellernas svar på cancerläkemedel vinblastin och doxorubicin. READ MORE

  4. 3. Evaluation of performance of MSI detection tools using targeted sequencing data

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Satya Krishna Prasanna Kolluri; [2021]
    Keywords : MSI; MSIcallers; Insilico dilutions; subsampling;

    Abstract : In recent years, digitalization and computer-based technologies have greatly revolutionized the field of bioinformatics. Advance research and development of computer-based programs have enhanced various DNA sequencing technologies. READ MORE

  5. 4. Building a genomic variant based prediction model for lung cancer toxicity

    University essay from KTH/Tillämpad fysik

    Author : Vincent Janvid; [2021]
    Keywords : cancer; bioinformatics; genomics; cancer; bioinformatik; genomik;

    Abstract : Since the completion of the the Human genome project in 2003, the evident complexity of our genome and its regulation has only grown. The idea that having sequenced the human genome would solve this mystery was quickly discarded. READ MORE

  6. 5. Non-coding constraint mutations impact the gene regulatory system in osteosarcoma

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi; Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Raphaela Pensch; [2021]
    Keywords : cancer; osteosarcoma; cancer genomics; evolutionary constraint; non-coding mutations; gene regulation;

    Abstract : The non-coding space makes up around 98 % of the genome, but cancer-driving mutations have so far mostly been discovered in protein-coding regions. The majority of somatic non-coding mutations are neutral passenger mutations and identifying non-coding mutations with driving roles in cancer poses a challenge. READ MORE