Essays about: "Cancer mutations"

Showing result 11 - 15 of 50 essays containing the words Cancer mutations.

  1. 11. Identification of de novo Transcription Factor Binding Motifs Created by Cancer-related Mutations

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Siqi Li; [2022]
    Keywords : transcription factor binding motifs; funMotifs; PCAWG; mutations; de novo motifs;

    Abstract : In many countries, cancer is one of the biggest threats for citizens’ health, especially among aged people. Genomic mutations play a crucial role in cancer cell development. In previous decades, cancer research has been mainly focused on mutations in coding regions. READ MORE

  3. 12. Cancer Driver Gene Detection using Deep Convolutional Neural Networks on H3K4me3 Enrichment Profiles

    University essay from Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation

    Author : Marc Pielies Avellí; [2022]
    Keywords : Cancer Driver CD Gene; Histone Post-Translational Modifications PTMs ; Convolutional Neural Networks CNNs .; Physics and Astronomy;

    Abstract : In spite of our current knowledge regarding the biology underlying cancer genesis, reliable methods for the discovery of cancer driver (CD) genes are still in great need. The rather recent incorporation of epigenetic markers to the cancer paradigm has nevertheless opened the door for the development of new computational approaches to the problem. READ MORE

  4. 13. Systems biology of deregulated splicing in cancer. A pan-cancer analysis of dysfunctional splicing machinery and alternative splicing events.

    University essay from

    Author : Leticia Castillon; [2021-08-06T14:57:24Z 2021-08-06T14:57:24Z 2021 2020]
    Keywords : multi-omics; splicing; alternative splicing; deep learning; cancer; transcriptome;

    Abstract : The deregulation or disruption of the splicing process has been shown to play a role in the onset, development, and even response to treatment of some malignancies. Partly due to our incomplete understanding of the mechanism and regulation behind splicing and alternative splicing, the importance of aberrant splicing in oncogenesis is not yet understood. READ MORE

  5. 14. Impact of insulin, glucagon and the I-G complex on cell viability and metabolism in Panc-1

    University essay from Högskolan i Skövde/Institutionen för hälsovetenskaper

    Author : Katarina Brantingson Skogfält; [2021]
    Keywords : ;

    Abstract : Cancer has been found not only to be a disease of genetic mutations, but also a metabolic state by which insulin and glucagon has an impact on cancer cells. Pancreatic adenocarcinoma (PDAC) is a highly lethal cancer with high risk of recurrence of cancer cells after cancer therapy treatment with a worse outcome. READ MORE

  6. 15. Structure-based design of novel pharmacological tools for the A3 adenosine G protein-coupled receptor

    University essay from Uppsala universitet/Institutionen för läkemedelskemi

    Author : Ashish Tamhankar; [2021]
    Keywords : ;

    Abstract : Adenosine receptors (ARs) are a family belonging to the GPCR superfamily, involved with multiple physiological processes and widely distributed throughout the body. In this study, we focus on the A3 AR due to its vast scale applications in various pathophysiological conditions such as inflammation, pain, allergic asthma, and cancer chemotherapy. READ MORE