Essays about: "High Throughput Screening"

Showing result 1 - 5 of 36 essays containing the words High Throughput Screening.

  1. 1. Novel tools for high-throughput genetic engineering, selection, and screening for improved Biotin production in E. coli cell factories

    University essay from Lunds universitet/Bioteknik (master); Lunds universitet/Bioteknik (CI)

    Author : Wibke Vellguth; [2023]
    Keywords : biotin; BioB; biotin synthase; oxidative stress; E. coli; biotechnology; Biology and Life Sciences;

    Abstract : Biotin is an essential co-factor in various metabolic processes and is crucial for the growth and maintenance of living organisms. The market need for biotin is multifaceted and driven by its importance in human health, beauty and cosmetics applications, pharmaceuticals, animal nutrition, and other industries. READ MORE

  3. 2. The Synthesis and Development of Potential Small Molecule Splice Modifiers toward a central nervous system (CNS) target for the treatment of a genetic disease

    University essay from KTH/Kemiteknik

    Author : Flore Miomandre; [2023]
    Keywords : organic synthesis; medicinal chemistry; pharmaceutical candidate; small molecule; genetic disease; organisk syntes; läkemedelskemi; läkemedelskandidat; småmolekylär; genetisk sjukdom;

    Abstract : Behandling av sällsynta sjukdomar är en stående utmaning inom läkemedelskemi då mer än 400 miljoner människor lider av 7000 olika sällsynta sjukdomar där få godkända läkemedel finns tillgängliga. Fokus för detta arbete är att syntetisera läkemedelskandidater för en sällsynt och livslång form av epilepsi med frekventa och långvariga anfall. READ MORE

  4. 3. Orphan G-Protein Coupled Receptors : Can we deorphanize the remaining orphans despite all the challenges?

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Micaela Andersson; [2022]
    Keywords : Deorphanization; Heterodimerization; High-throughput screening; Orphan G-protein Coupled receptor; Pseudogenes; Reversed pharmacology;

    Abstract : G-protein coupled receptors (GPCRs) play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, which have resulted in 34% of all FDA-approved drugs which target GPCRs. The human genome encodes for approximately 800 GPCR members of which about 140 non-olfactory receptors remain orphans with an unknown function and endogenous ligand. READ MORE

  5. 4. Pipeline for Next Generation Sequencing data of phage displayed libraries to support affinity ligand discovery

    University essay from Uppsala universitet/Institutionen för immunologi, genetik och patologi

    Author : Ella Schleimann-Jensen; [2022]
    Keywords : NGS; next generation sequencing; phage display; affinity ligands; data analysis; bioinformatics;

    Abstract : Affinity ligands are important molecules used in affinity chromatography for purification of significant substances from complex mixtures. To find affinity ligands specific to important target molecules could be a challenging process. Cytiva uses the powerful phage display technique to find new promising affinity ligands. READ MORE

  6. 5. Developing complementary supercritical fluid chromatographic methods for a high throughput purification process

    University essay from Karlstads universitet

    Author : Alma Söderström; [2022]
    Keywords : Supercritical Fluid Chromatography; Pharmaceutical Industry; Column screening; Green chemistry; Superkritisk vätskekromotografi; Läkemedelsindustri; Kolonn set; Grön kemi;

    Abstract : Supercritical fluid chromatography (SFC) is an expanding chromatographic technique that is part of the evolving field of green chemistry due to its short run times and use of non-toxic solvents in combination with recycled CO2. The use of a suitable column is essential for separation science in general and there is a wide variety of SFC compatible columns available on the market. READ MORE