Essays about: "Unbound concentration"

Found 4 essays containing the words Unbound concentration.

  1. 1. Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma

    University essay from KTH/Tillämpad fysikalisk kemi

    Author : Leona Clarin; [2020]
    Keywords : Unbound concentration; free concentration; ultrafiltration; LC-MS MS; cefotaxime; flucloxacillin; cloxacillin; piperacillin; Fri fraktion; ultrafiltrering; LC-MS MS; cefotaxim; flukloxacillin; kloxacillin; piperacillin;

    Abstract : Infections in critically ill patients are a problem for the healthcare system and at any one time, 70 % of all intensive care unit (ICU) patients are treated with antibiotics. Antibiotics bind toproteins in the blood, but only unbound drug can diffuse over capillary membranes and bindto the targeted receptor. READ MORE

  3. 2. Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Leona Clarin; [2020]
    Keywords : unbound; LC-MS MS; beta-lactam; antibiotics; ultrafiltration; proteinbindning; koncentration; antibiotika; beta-laktam; ultrafiltrering;

    Abstract : Kritiskt sjuka patienter med infektioner är en börda för sjukvården och 70 % av alla patienter på intensivvårdsavdelningar är ordinerade antibiotika. Antibiotika binder till proteiner i blodet, men enbart den icke-proteinbundna (fria) fraktionen kan diffundera över kapillära membran och binda till receptorer. READ MORE

  4. 3. Integration of microfluidic sample handlingwith ultra-sensitive magnetic bioassay usinghigh-Tc Superconducting Quantum InterferenceDevice readout

    University essay from Uppsala universitet/Nanoteknologi och funktionella material

    Author : Emil Eriksson; [2016]
    Keywords : ;

    Abstract : Immunoassays are a very sensitive molecular diagnostics technique that uses biochemical reactions to measure concentration of biomolecules in a solution. ELISA is one of the most commonly used type, based on fluorescence, in routine medicaldiagnostics. It is time consuming and requires relatively large sample volumes. READ MORE

  5. 4. Building predictive unbound brain-to-plasma concentration ratio (Kp,uu,brain) models

    University essay from Lunds universitet/Examensarbeten i bioinformatik

    Author : Srinidhi Varadharajan; [2014]
    Keywords : Biology and Life Sciences;

    Abstract : Abstract The blood-brain barrier (BBB) constitutes a dynamic membrane primarily evolved to protect the brain from exposure to harmful xenobiotics. The distribution of synthesized drugs across the blood-brain barrier (BBB) is a vital parameter to consider in drug discovery projects involving a central nervous system (CNS) target, since the molecules should be capable of crossing the major hurdle, BBB. READ MORE