Essays about: "evaluate monoclonal antibody"

Showing result 1 - 5 of 10 essays containing the words evaluate monoclonal antibody.

  1. 1. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Jonathan Efverström; [2023]
    Keywords : Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

    Abstract : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. READ MORE

  3. 2. Improving antibody-based immunotherapy protocols in vitro : Study on optimization of antitumor immunity by antibody-dependent phagocytosis with the monoclonal antibody rituximab

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Giovanni Ferro; [2022]
    Keywords : ;

    Abstract : The monoclonal antibody Rituximab (RTX) has been widely and successfully used to treat non-Burkitt B cell lymphoma in human patients. The combination of immunotherapy with low-dose chemotherapy has increased the success of the treatment and translated into increased patients’ survival. READ MORE

  4. 3. Efficacy and Safety of Secukinumab in Treating Psoriasis Vulgaris

    University essay from Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Author : Randy Pham; [2022]
    Keywords : Plaque psoriasis; psoriasis vulgaris; secukinumab; monoclonal antibody; IL-17A;

    Abstract : Introduction. Plaque psoriasis (psoriasis vulgaris) is a chronic disease and the most common type of psoriasis. It is charactarized by well-defined areas with silvery scaling, erythema, puritus and sometimes pain. Psoriasis affects about 1. READ MORE

  5. 4. A high-throughput method for screening of protein binding behavior of multimodal anionic exchange ligands

    University essay from Uppsala universitet/Analytisk farmaceutisk kemi

    Author : Ani Avedis; [2021]
    Keywords : Multimodal chromatography; multimodal anionic exchange ligands; product development; purification process; biological drugs; resins;

    Abstract : The biopharmaceutical industry is constantly developing biological drugs, resulting in increased levels of product related impurities having similar characteristics as the target. The aim of the ligand project was to address future challenging purifications by developing new ligands for future resins for the biopharmaceutical industry. READ MORE

  6. 5. Development of a high-throughput platform for generation and early screening of high producing stable cell lines

    University essay from KTH/Proteinvetenskap

    Author : Jonathan Karlsson Persson; [2021]
    Keywords : CHO-K1; HEK293; CellCelector™; High-throughput screening; Protein A beads; Secondary antibody; CHO-K1; HEK293; CellCelector™; Högkapacitets-screening; Protein A-kulor; Sekundär antikropp;

    Abstract : Produktionen av rekombinanta biofarmaceutiska läkemedel, exempelvis monoklonala antikroppar, är en oumbärlig men ansträngande process. Under 2019 var sju av de tio mest sålda läkemedlen globalt baserade på rekombinant producerade monoklonala antikroppar. READ MORE