Essays about: "Drug evaluation"

Showing result 1 - 5 of 86 essays containing the words Drug evaluation.

  1. 1. Evaluation of different block-copolymer coatings of iron oxide nanoparticles by flash nanoprecipitation

    University essay from KTH/Fiber- och polymerteknologi

    Author : Felix Bogdan; [2023]
    Keywords : Nanopartiklar; organisk katalysator; ROP; block-sampolymerer PL G A; oljesyra IONPs; Nanoparticles; organic catalyst; ROP; block-copolymers PL G A; oleic acid IONPs;

    Abstract : Nanopartiklar (NP) erbjuder unika möjligheter för medicinska tillämpningar, inklusive kontrollerad frisättning av cancerläkemedel, användning som bildkontrast vid avbildningsprocedurer eller hypertermisk behandling av cancerceller. Flash nanoprecipitation (FNP) producerar NPs för att kombinera dessa tillämpningar i en snabb, billig och skalbar beläggningsprocess. READ MORE

  3. 2. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    University essay from Uppsala universitet/Theranostics

    Author : Astrid Haraldsson; [2023]
    Keywords : PNA; pretargeting; cancer therapy; cytotoxic payload;

    Abstract : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. READ MORE

  4. 3. Design and Evaluation of Peptide Binders : In silico evaluation and comparison of generative AI for de novo peptide binder design

    University essay from Uppsala universitet/Beräkningsbiologi och bioinformatik

    Author : Linde Brokmar; [2023]
    Keywords : Protein design; de novo design; protein engineering; generative ai; machine learning; peptide binders; AF2; EvoBind; RFdiffusion; ProteinMPNN;

    Abstract : Peptide binders are short proteins that bind to larger proteins. Due to peptide binders having high specificity and being cheap to synthesize, they are a prime candidate for drug design. Creating new proteins in silico can be divided into three steps: protein backbone generation, sequence design, and computational filtering. READ MORE

  5. 4. Fysiologiska effekter vid stående och liggande immobilisering av asiatiska och afrikanska elefanter : praktisk utvärdering och litteraturstudie

    University essay from SLU/Dept. of Clinical Sciences

    Author : Tina Jansson; [2023]
    Keywords : afrikansk elefant; alfa2-adrenoceptoragonist; asiatisk elefant; fysiologi; immobilisering; opioid; sedering; xylazin;

    Abstract : Elefanten är världens nu största landlevande däggdjur och alla tre arter som finns är listade som hotade av olika grad. Att immobilisera vilda elefanter är en del av det artbevarande arbetet. Även elefanter i djurparker och så kallade arbetselefanter kan behöva immobiliseras, till exempel för vård eller transporter. READ MORE

  6. 5. Accelerating a Molecular Docking Application by Leveraging Modern Heterogeneous Computing Systems

    University essay from KTH/Skolan för elektroteknik och datavetenskap (EECS)

    Author : Gabin Schieffer; [2023]
    Keywords : Molecular docking; AutoDock; GPU; Tensor Core; Drug Discovery; Molekylär dockning; AutoDock; GPU; Tensor Core; Läkemedelsutveckling;

    Abstract : In drug development, molecular docking methods aim at characterizing the binding of a drug-like molecule to a protein. In a typical drug development process, a docking task is repeated millions of time, which makes optimization efforts essential. READ MORE