Advanced search

Showing result 6 - 10 of 12 essays matching the above criteria.

  1. 6. The genetics of glioma : and the use of dogs as model for human glioma

    University essay from SLU/Dept. of Animal Breeding and Genetics

    Author : Vanja Börjesson; [2016]
    Keywords : c-MET; canine; gene therapy; genome wide association studies GWAS ; next generation sequencing NGS ; glioma;

    Abstract : Glioma is the most common type of primary brain tumor in humans, and the second most common in canines. This tumor type originates from glial cells in the brain and is a genetic disorder caused by mutations in genes regulating important cellular functions. The current diagnosis of glioma is based on histopathological evaluations and gradings. READ MORE

  3. 7. Analysis of PIK3CA mutations in tumours from patients with non-small cell lung cancer using pyrosequencing

    University essay from Uppsala universitet/Institutionen för kvinnors och barns hälsa

    Author : Jennifer Jonasson; [2014]
    Keywords : PI3K; tumour marker; pseudogene; oncogene; targeted therapy;

    Abstract : A subgroup of non-small cell lung cancer (NSCLC) cases harbour mutations in classical oncogenes, which can affect therapy response and prognosis. By therapeutically targeting the corresponding proteins with inhibitory drugs, the clinical outcome for these lung cancer patients may be improved. READ MORE

  4. 8. Process development for the production of a therapeutic Affibody® Molecule

    University essay from Institutionen för biologisk grundutbildning

    Author : Belinda Fridman; [2014]
    Keywords : Affibody® Molecule; HER3; EGFR; HER2; cancer therapy; process development; DOE; multivariate data analysis; E. coli; ABD; plasma half-life; thermolysis; fed-batch; gluconoylation; BL21 DE3 ; T7 expression system;

    Abstract : Recently HER3, member of the epidermal growth factor receptor family (EGFR), has been found to play a crucial role in the development of resistance towards inhibitors that are given to patients with HER1- and HER2-driven cancers. As HER3 is up-regulated or over-activated in several types of human cancers, it is of outmost importance that new innovative drugs target its oncologic activity. READ MORE

  5. 9. The importance og LRIG1 in lung cancer

    University essay from Onkologi

    Author : Samuel Kvarnbrink; [2012]
    Keywords : lungcancer; EGFR; LRIG1;

    Abstract : .... READ MORE

  6. 10. Genetic heterogeneity of EGFR and KRAS mutations in primary tumor tissue from non-small cell lung cancer patients

    University essay from Institutionen för medicinsk biokemi och mikrobiologi

    Author : Johanna Mattsson; [2011]
    Keywords : Non-small cell lung cancer; KRAS; EGFR; heterogeneity; mutation;

    Abstract : Activated epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations characterize molecular subgroups of non-small cell lung cancer (NSCLC) and have a strong predictive value for response to EGFR inhibitor therapy. Recently, EGFR mutation testing was included in the diagnostic algorithm of NSCLC. READ MORE