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Showing result 1 - 5 of 6 essays matching the above criteria.

  1. 1. Genetic manipulation to improve efficacy of dendric cell adoptive immunotherapy against cancer in dogs

    University essay from Karlstads universitet

    Author : Felicia Berglund; [2023]
    Keywords : Adoptive immunotherapi;

    Abstract : To improve the efficacy of the dendritic cell vaccine Alv B DC from Alv B, the PD-L1 expression in cancer cells was attempted to be reduced through a transfection with a custom designed siRNA. Before transfecting the dendritic cells, the siRNA functionality had to be tested through flow cytometry, that resulted in negative results and therefore led to a RT-qPCR protocol that indicated that the siRNA was functional. READ MORE

  3. 2. Molecular mapping of the HGSOC tumour microenvironment

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Philippine Louail; [2023]
    Keywords : Immunology; Ovarian cancer; Multiplex Immunofluorescence; scRNA sequencing; Bioinformatics; Image analysis;

    Abstract : High-grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer, and its heterogeneity poses a challenge for the discovery of reliable diagnostic biomarkers, therapeutic targets, and predicting treatment response, particularly to immunotherapy. The current standard diagnostic and treatment options are inadequate, resulting in late diagnosis and poor prognosis. READ MORE

  4. 3. Evaluating LOAd703 in combination with chemotherapeutic agents in ovarian cancer

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Institutionen för immunologi, genetik och patologi

    Author : Jonas Härdin; [2022]
    Keywords : Clinical Immunology; Immunotherapy; LOAd; Ovarian Cancer; Oncology; Virus;

    Abstract : Ovarian cancer is a disease with a high rate of mortality where the need for novel treatments will increase in the near future as older and populous generations reach the age where the cancer is usually diagnosed. Once treated, ovarian cancer tends to recur and display a newfound resistance against the platinum-based chemotherapeutic drugs that are used to treat the disease. READ MORE

  5. 4. Investigation Of Human Cancer Immune Interaction Using In Vitro Assays

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Irineos Papakyriacou; [2020]
    Keywords : Cancer immunotherapy; nivolumab; durvalumab;

    Abstract : Cancer immunotherapy, including immune checkpoint blocking antibodies are important components for treatment of patients with various types of cancer as they enhance the ability of the immune system to fight tumours. However, tumor cells have the ability to develop resistance to a variety of transitional therapies such as chemotherapy. READ MORE

  6. 5. Intratumoral heterogeneity in early breast cancer

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : MARIA STOGIANNITSI; [2020]
    Keywords : breast cancer; RNAscope technique; heterogeneity of BC; RNA in situ hybridization;

    Abstract : The use of adjuvant The use of adjuvant polychemotherapy (ACT) confers unequivocal benefits in terms of relapse free (RFS) and overall survival (OS) after resection of early breast cancer (BC). Although the magnitude of benefit is the same regardless of clinicopathological factors such as ER expression or nodal stage, it is clear that a substantial proportion of patients will eventually relapse and succumb to the disease. READ MORE