Essays about: "scRNA sequencing"

Showing result 1 - 5 of 9 essays containing the words scRNA sequencing.

  1. 1. Regulatory Driven Clustering of Single-Cell Data; Clustering of single-cell RNA sequencing from glioblastoma with a novel mathematical method

    University essay from Göteborgs universitet/Institutionen för matematiska vetenskaper

    Author : Kári Kristjánsson; [2023-08-08]
    Keywords : ;

    Abstract : Cancer is a leading cause of death worldwide. Single-cell RNA sequencing has arisen as an important method to explore the gene expression of biological cells, including cancer cells. In this study, we deployed a computational algorithm known as ScRegClust to dissect single-cell RNA-sequencing (scRNA-seq) data from brain tumors. READ MORE

  2. 2. Developing Automated Cell Segmentation Models Intended for MERFISH Analysis of the Cardiac Tissue by Deploying Supervised Machine Learning Algorithms

    University essay from KTH/Kemi

    Author : Julia Rune; [2023]
    Keywords : Cell Segmentation; Cellpose; Supervised Machine Learning; MERFISH; Heart Failure; Cellsegmentering; Cellpose; Övervakad Maskininlärning; MERFISH; Hjärtsvikt;

    Abstract : Följande studie behandlar utvecklandet av automatiserade cellsegmenteringsmodeller med avsikt att identifiera gränser mellan celler i hjärtvävnad. Syftet är att möjliggöra analys av data genererad från multiplexed error-robust in situ hybridization (MERFISH). READ MORE

  3. 3. Single-cell RNA-seq mapping of chicken leukocytes : An investigation into single-cell transcriptomics as an alternative to traditional immunological methods within non-traditional model organisms

    University essay from Uppsala universitet/Mikrobiologi och immunologi

    Author : Matilda Maxwell; [2023]
    Keywords : Bioinformatics; scRNA-seq; avian; immunology; Seurat; leukocytes; chicken; gallus gallus; 10x genomics; PCA;

    Abstract : The immune system is a complex infrastructure where many cells interact with each other and perform duties depending on their type and function. When using traditional immunological methods in studying non-traditional model organisms, such as birds, challenges arise. READ MORE

  4. 4. Molecular mapping of the HGSOC tumour microenvironment

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Philippine Louail; [2023]
    Keywords : Immunology; Ovarian cancer; Multiplex Immunofluorescence; scRNA sequencing; Bioinformatics; Image analysis;

    Abstract : High-grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer, and its heterogeneity poses a challenge for the discovery of reliable diagnostic biomarkers, therapeutic targets, and predicting treatment response, particularly to immunotherapy. The current standard diagnostic and treatment options are inadequate, resulting in late diagnosis and poor prognosis. READ MORE

  5. 5. Benchmarking of computational methods for Spatial Transcriptomics Data analysis

    University essay from KTH/Proteinvetenskap

    Author : Nima Taherpour; [2022]
    Keywords : Spatial Transcriptomics; Scanpy; Squidpy; Giotto; Seurat;

    Abstract : Ökningen av sekvenseringsdata har skapat ett behov av att ta fram nya och flexibla analysmetoder för att kunna analysera datan. Många sekvenseringsteknologier har utvecklats genom åren, med olika syften och de är idag mer specialiserade. READ MORE