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1. 1. Non-coding constraint mutations impact the gene regulatory system in osteosarcoma

   University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi; Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Raphaela Pensch; [2021]
   Keywords : cancer; osteosarcoma; cancer genomics; evolutionary constraint; non-coding mutations; gene regulation;

   Abstract : The non-coding space makes up around 98 % of the genome, but cancer-driving mutations have so far mostly been discovered in protein-coding regions. The majority of somatic non-coding mutations are neutral passenger mutations and identifying non-coding mutations with driving roles in cancer poses a challenge. READ MORE