Essays about: "TKI"
Found 3 essays containing the word TKI.
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1. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics
University essay from Lunds universitet/Institutionen för immunteknologiAbstract : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. READ MORE
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2. Validation and optimization of multiplexInSitu PLA for signalling pathway analysis
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : With the advent of Tyrosine kinase inhibitors (TKI) as a therapy for Chronic myeloid Leukemia (CML), the patients now enjoy a life expectancy close to that of the general population. But some patients do get unresponsive to the TKI treatment over time due to several mutations in the kinase domain of the BCR-ABL fusion protein, which further leads to activation of multiple signaling cascades within the leukemic cell, helping it survive and proliferate. READ MORE
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3. Characterisation of EGFR and KRAS mutations in non-small cell lung cancer
University essay from Institutionen för medicinsk biokemi och mikrobiologiAbstract : Background: Lung cancer is the leading cause of cancer-related death and one of the most common cancer types worldwide. Epidermal growth factor receptor (EGFR) has been shown to be an important therapeutic target in non-small cell lung cancer. READ MORE
