Essays about: "affibody library"

Found 2 essays containing the words affibody library.

  1. 1. Selection and Characterisation of Affibody Molecules Intended for Drug Conjugates Targeting Cancer Cells

    University essay from KTH/Proteinvetenskap

    Author : Elin Hedberg; [2022]
    Keywords : Affibody; AffiDC; affibody-drug conjugate; urothelial cancer; cell display; affibody library;

    Abstract : Affibodymolekyler är små affinitetsproteiner (6.5 kDa) som föreslås kunna ersätta monoklonala antikroppar i terapeutiska tillämpningsområden, exempelvis i antikropp-läkemedelskonjugat (ADCs) som kan navigera sig fram till biomarkörer som är uttryckta på cancerceller. READ MORE

  3. 2. Bacterial Display of a Tau-Binding Affibody Construct:Towards Affinity Maturation

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Moira Ek; [2020]
    Keywords : Microtubule-associated protein tau; Neurodegenerative disorders; Alzheimer’s disease; Affibody molecules; Affinity maturation; Staphylococcal surface display; Escherichia coli display; Flow cytometry; Cell sorting;

    Abstract : Aggregation of microtubule-associated protein tau is involved in the pathology of several neurodegenerative diseases, including Alzheimer’s disease. The affibody TP4 has been shown to inhibit this aggregation process, and its target-binding positions were previously grafted onto a dimeric affibody scaffold, creating the sequestrin seqTP4. READ MORE