Essays about: "dissociation association rate constants"

Found 2 essays containing the words dissociation association rate constants.

1. 1. Evaluation of Rate Constants from Protein-Ligand Interactions with Weak Affinity Chromatography

   University essay from Institutionen för naturvetenskap, NV

   Author : Daniel Jönsson; [2012]
   Keywords : peak profile method; dissociation association rate constants; weak affinity chromatography; band-broadening;

   Abstract : The paradigm of drug discovery have been to find the strongest possible binder to the target by high-throughput screening (HTS) but high affinity interactions are related to low kinetic off rates and thus result in severe side-effects and non-approved drugs. Lead molecules working in a transient manner (KD > µM) will allow for rapid off rates and possibly less side-effects. READ MORE

3. 2. Determination of antibody affinity and kinetic binding constants in Gyrolab Bioaffy microfluidic CD

   University essay from Institutionen för fysik, kemi och biologi

   Author : Mikael Karlsson; [2008]
   Keywords : Affinity constants; Equilibrium dissociation constants; Kinetic rate constants; Immunoassay; Monoclonal antibodies; Microfluidics; Gyrolab Bioaffy; Microlaboratory; Compact disc;

   Abstract : Studies of binding reactions are of highest importance in a vast number of areas of biomedicine and biotechnology. A demand for fast and accurate small-volume measurements grows stronger, partly due to the development of therapeutic antibodies. In this report, a novel method for studies of binding reactions of antibodies is described. READ MORE