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Found 3 essays matching the above criteria.

1. 1. Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Albin Leding; [2021]
   Keywords : Pharmacokinetics; Pharmacometrics; Pharmacology; population pharmacokinetics; physiologically-based pharmacokinetics; in vitro to in vivo extrapolation; IVIVE; PBPK; PK; popPK; tuberculosis; model informed approach; first in vivo pharmacokinetic experiment; mouse; mice; PKSim; NONMEM; in vitro; in vivo;

   Abstract : Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. READ MORE

3. 2. Models for predicting efflux transport over the blood-brain barrier

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Marjaneh Janani; [2020]
   Keywords : efflux transport; brain; blood-brain-barrier; Verapamil; Risperidone; Prazosin;

   Abstract : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. READ MORE

4. 3. Models for predicting efflux transport over the blood-brain barrier

   University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Author : Marjaneh Janani; [2020]
   Keywords : Efflux; blood-brain-barrier; modeling; transporter;

   Abstract : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. READ MORE