Essays about: "population pharmacokinetics"

Showing result 1 - 5 of 9 essays containing the words population pharmacokinetics.

  1. 1. Towards individualised anaesthesia: A comparison between target-controlled infusion and closed-loop control

    University essay from Lunds universitet/Institutionen för reglerteknik

    Author : Amanda Gustafsson; [2023]
    Keywords : Technology and Engineering;

    Abstract : Individualised healthcare is the future of medicine, due to the so called inter-patient variability. The inter-patient variability involves differences in the drug response between different patients. The effect of a drug can usually be divided into pharmacokinetics (PK) and pharmacodynamics (PD). READ MORE

  3. 2. Population Pharmacokinetics of Linezolid for Optimization of the Treatment for Multidrug Resistant Tuberculosis

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Viktor Hansen; [2022]
    Keywords : tuberculosis; drug resistance; pharmacometrics; pharmacokinetics; pop-pk; south africa; non linear mixed effects modelling; nlme;

    Abstract : Tuberculosis is one the leading causes of death globally and was before the COVID-19 pandemic the leading cause of death from a single infectious agent. Developing active tuberculosis is life threatening and therefore is the rise of drug-resistant tuberculosis alarming as this risk causing current treatments to become ineffective. READ MORE

  4. 3. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Osama Qutishat; [2022]
    Keywords : Machine learning; pharmacometrics; Neural networks; pop-pk;

    Abstract : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. READ MORE

  5. 4. Automatic Development of Pharmacokinetic Structural Models

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Alzahra Hamdan; [2022]
    Keywords : pharmacometrics; non-linear mixed effects; modelling; pharmacokinetics; NONMEM; automation; exhaustive algorithm; stepwise algorithm; structural models; inter-individual variability; residual error models; model selection;

    Abstract : Introduction: The current development strategy of population pharmacokinetic models is a complex and iterative process that is manually performed by modellers. Such a strategy is time-demanding, subjective, and dependent on the modellers’ experience. READ MORE

  6. 5. Comparison of Multiple Models for Diabetes Using Model Averaging

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Alex Al-Mashat; [2021]
    Keywords : pharmacometrics; population pharmacokinetics; pop-pk; pop-PK diabetes; model averaging; MA; cross-validation; cv; CV; akaike information criterion; Akaike; aic; AIC; MPG; mpg; FPG; fpg; FPI; fpi; HbA1c; hba1c; farmakometri; populationsfarmakokinetik; diabetes; model averaging; MA; cross-validation; cv; CV; akaike; Akaike; aic; AIC; MPG; mpg; FPG; fpg; FPI; fpi; HbA1c; hba1c;

    Abstract : Pharmacometrics is widely used in drug development. Models are developed to describe pharmacological measurements with data gathered from a clinical trial. The information can then be applied to, for instance, safely establish dose-response relationships of a substance. READ MORE