Essays about: "secretion"

Showing result 21 - 25 of 135 essays containing the word secretion.

1. 21. Nanoscale detection of insulin granule sub-structures using dSTORM imaging

   University essay from Lunds universitet/Atomfysik; Lunds universitet/Fysiska institutionen

   Author : Yu Hong; [2020]
   Keywords : islet β-cells; dSTORM imaging; Alexa Fluor 647; Physics and Astronomy;

   Abstract : Diabetes mellitus is a global disease, mainly caused by insufficient insulin secre- tion from pancreatic islet β-cells. Insulin is stored in the granules of islet β-cells and released in response to extracellular stimuli e.g. glucose. READ MORE

3. 22. The role of salt inducible kinases in the regulation of the mammalian target of rapamycin pathway in adipocytes

   University essay from Lunds universitet/Examensarbeten i molekylärbiologi

   Author : Sulochana Kotresh Jali; [2020]
   Keywords : Biology and Life Sciences;

   Abstract : Salt inducible kinase 2 (SIK2) is found abundantly in adipose tissue and may have a role in the development of diabetes. SIK2 is downregulated in insulin-resistant and obese individuals, thereby providing a new potential target for therapeutic solutions. READ MORE

4. 23. Optimizing signal peptides for expression of recombinant antibodies in HEK293 cells

   University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

   Author : Gustav Myhrinder; [2020]
   Keywords : Signal peptide; antibody; mammalian cell; HEK293; secretory pathway;

   Abstract : Monoclonal antibodies are well-established as a therapeutic in the biopharmaceutical market, targeting a variety of diseases and with 79 approved products by the United States Food and Drug Administration in December 2019. Therapeutic monoclonal antibodies are commonly produced as recombinant proteins in mammalian cell lines, due to their capacity of post-translational modifications, most notably glycosylation. READ MORE

5. 24. Production and validation of anti-HCV antibodies for viral neutralization

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Megan Olga García Mark; [2020]
   Keywords : Cloning; antibody; infection; HCV; IgG production; molecular biology; cell factory; plasmid design; immunology;

   Abstract : Hepatitis-C Virus (HCV) remains the leading cause of liver transplant in the US and the UK, and the World Health Organization (WHO) estimates that 71 million people are infected worldwide. A vaccine would drastically impact the healthcare-associated burdens that HCV causes globally. READ MORE

6. 25. Characterization of cellular enzymatic activity through functional single cell analysis using DropMap

   University essay from Lunds universitet/Institutionen för immunteknologi

   Author : Linnea Gidner; [2020]
   Keywords : Single-cell analysis; enzymatic activity; cell heterogeneity; Biology and Life Sciences;

   Abstract : Assuming normal distribution within cell populations has long been status quo in cellular research. With the fast development of techniques, numerous examples of heterogeneites within isogenic cultures have been unveiled, demonstrating the need of single cell analysis. READ MORE