Essays about: "BCRP"

Showing result 1 - 5 of 11 essays containing the word BCRP.

  1. 1. In silico and in vitro determination of substrate specificity for Breast Cancer Resistance Protein (BCRP) transporter at the blood-brain barrier

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Fen Wang; [2021]
    Keywords : BCRP; substrate specificity; BBB; ATP-binding cassette ABC transporter; Drug transport;

    Abstract : Background The Breast Cancer Resistance Protein (BCRP) drug transporter is important for drug disposition and plays a critical role in regulating drug entry into the brain. Its substrate spectrum overlaps with substrates of Multi Drug Resistance Protein 1 (MDR1, P-gp), which influences and complicates the interpretation of data on drug distribution into tissues (e. READ MORE

  3. 2. Models for predicting efflux transport over the blood-brain barrier

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Marjaneh Janani; [2020]
    Keywords : efflux transport; brain; blood-brain-barrier; Verapamil; Risperidone; Prazosin;

    Abstract : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. READ MORE

  4. 3. Models for predicting efflux transport over the blood-brain barrier

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Marjaneh Janani; [2020]
    Keywords : Efflux; blood-brain-barrier; modeling; transporter;

    Abstract : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. READ MORE

  5. 4. Effekten av sulforafan på genuttrycket av breast cancer resistance protein i MCF-7 celler

    University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Author : Karolina Sjöberg; [2015]
    Keywords : sulforafan; breast cancer resistance protein; BCRP; nuclear factor E2-related factor-2; Nrf2; MCF-7; bröstcancerceller; mjölk; sulforaphane; breast cancer resistance protein; breast cancer cells; milk;

    Abstract : Sulforafan är en isothiocyanat-förening som finns i stora mängder i olika kålväxter. Sulforafan har setts ha en kemopreventiv inverkan bland annat genom att inducera fas II-enzymer styrda av transkriptionsfaktorn nuclear factor E2-related factor-2 (Nrf2). READ MORE

  6. 5. Toxicological effects of food additives azo dyes

    University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Author : Cristina Gil; [2014]
    Keywords : endocrine disruptor; Human adrenocortical H295R ; cell line; azo dyes; MTT assay;

    Abstract : BACKGROUND: Azo dyes are widely used in foods, pharmaceuticals and cosmetics. They have been tested in several screenings regarding their effects on human health, but very little data is available on endocrine disrupting effects. READ MORE