Essays about: "CLASS A DRUG"

Showing result 1 - 5 of 37 essays containing the words CLASS A DRUG.

  1. 1. Creating a High-Throughput Workflow for Automated Peptide Characterization using LC-MS

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Sara Forsberg; [2023]
    Keywords : High-throughput analysis; Impurity profiling; UHPLC-HRMS; Peptide characterization; Peptide descriptors; Analytical chemistry; Technology and Engineering;

    Abstract : In the early stage of a drug discovery project, there is a need for efficient methods that can analyse peptides in short time. This includes methods that confirm the peptide’s identity and estimates its relative purity in an efficient and reliable way. READ MORE

  3. 2. Investigation into methods for N-trifluoromethylation of a key intermediate in the synthesis of an SGLT1 inhibitor and potential starting point for anti-diabetes drugs

    University essay from Uppsala universitet/Preparativ läkemedelskemi

    Author : Alfred Larsson; [2023]
    Keywords : SGLT; SGLT1; diabetes; trifluoromethyl; N-trifluoromethylation;

    Abstract : Sodium-glucose transporters (SGLTs) are a group of membrane proteins involved in regulating blood-glucose levels. Compounds which inhibit SGLTs are therefore of interest in the development of new treatments for diabetes. READ MORE

  4. 3. The battle against sepsis : exploring the genotypic diversity of pseudomonas and proteus clinical isolates

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Suud Ahmed; [2023]
    Keywords : ;

    Abstract : Sepsis is a dangerous and potentially fatal condition that has a mysterious origin, underscoring the significance of prompt and accurate diagnosis and treatment. Bacterial whole-genome sequencing, which is widely used in clinical microbiology, stands at the forefront of sequencing technologies, particularly to combat sepsis. READ MORE

  5. 4. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

    University essay from Lunds universitet/Institutionen för immunteknologi

    Author : Johan Thorsson; [2023]
    Keywords : Biology and Life Sciences;

    Abstract : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. READ MORE

  6. 5. Drug Design of β-Lactamase Inhibitors of the DBO-scaffold against OXA-48 : A Molecular Dynamics Study of Ligand Stability in the Michaelis Complex

    University essay from Uppsala universitet/Läkemedelsdesign och läkemedelsutveckling

    Author : Linda Liljeholm; [2022]
    Keywords : OXA-48; β-lactamase; DBO inhibitors; diazabicyclooctane; avibactam; relebactam; β-lactamase inhibitor; BLI; molecular dynamics; LIE; Linear Interaction Energy; antibiotic resistance; drug design;

    Abstract : The emergence of β-lactamase-mediated antibiotic resistance is one of the biggest threats in modern times. Combined with the discovery void of new forms of antibiotics, this sets the course toward a future where the efficacy of present-day health care will be jeopardized. READ MORE