Essays about: "OXA-48"

Found 3 essays containing the word OXA-48.

  1. 1. Drug Design of β-Lactamase Inhibitors of the DBO-scaffold against OXA-48 : A Molecular Dynamics Study of Ligand Stability in the Michaelis Complex

    University essay from Uppsala universitet/Läkemedelsdesign och läkemedelsutveckling

    Author : Linda Liljeholm; [2022]
    Keywords : OXA-48; β-lactamase; DBO inhibitors; diazabicyclooctane; avibactam; relebactam; β-lactamase inhibitor; BLI; molecular dynamics; LIE; Linear Interaction Energy; antibiotic resistance; drug design;

    Abstract : The emergence of β-lactamase-mediated antibiotic resistance is one of the biggest threats in modern times. Combined with the discovery void of new forms of antibiotics, this sets the course toward a future where the efficacy of present-day health care will be jeopardized. READ MORE

  3. 2. Antibiotic combination therapies against carbapenamse producing Klebsiella pneumoniae

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Thomas Söderhäll; [2021]
    Keywords : Klebsiella pneumoniae; carbapenem resistance; carbapenemase; combination therapy; meropenem; colistin; avibactam; constucts; porins;

    Abstract : The treatment options for multidrug resistant bacteria are dwindling and it is an important issue of research in medicine to solve. One of the more problematic bacterial species is Klebsiella pneumoniae, it can cause infections with high morbidity that are difficult to treat. READ MORE

  4. 3. Screening for double carbapenem therapies effective against multidrug resistant Enterobacteriaceae

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Karin Vickberg; [2019]
    Keywords : Combination therapy; Carbapenem resistance; Carbapenemase; Carbapenem-resistant Enterobacteriaceae CRE ; Carbapenemase-producing Enterobacteriaceae; Klebsiella pneumoniae carbapenemase KPC ; New Delhi metallo-b-lactamase NDM ; Oxacillinase OXA ; Ertapenem ETP ; Doripenem DOR ; Meropenem MEM ; Broth microdilution BMD ; Time-lapse microscopy oCelloScope ; Time-kill experiments; Synergy;

    Abstract : Multidrug resistant bacteria account for one of the biggest threats to human health in the future. One treatment option to be evaluated is antibiotic combination therapy. For this purpose, last- line carbapenems have been suggested, even when bacteria are resistant, e.g. READ MORE