Essays about: "Histone modifications"

Showing result 1 - 5 of 6 essays containing the words Histone modifications.

  1. 1. Cancer Driver Gene Detection using Deep Convolutional Neural Networks on H3K4me3 Enrichment Profiles

    University essay from Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation

    Author : Marc Pielies Avellí; [2022]
    Keywords : Cancer Driver CD Gene; Histone Post-Translational Modifications PTMs ; Convolutional Neural Networks CNNs .; Physics and Astronomy;

    Abstract : In spite of our current knowledge regarding the biology underlying cancer genesis, reliable methods for the discovery of cancer driver (CD) genes are still in great need. The rather recent incorporation of epigenetic markers to the cancer paradigm has nevertheless opened the door for the development of new computational approaches to the problem. READ MORE

  3. 2. Histone modifications and their role in splicing

    University essay from Linköpings universitet/Biologi

    Author : Anna Wettermark; [2020]
    Keywords : Splicing; Spliceosome; Histone modifications; epigenetics; histone methylation; histone acetylation; histone phosphorylation; histone ubiquitination;

    Abstract : Splicing is the process when introns gets removed and exons are spliced together. This is an important step to form a clean mRNA with no unnecessary sequences that could interrupt protein synthesis. There are different types of splicing and some of them need a complex called spliceosome. READ MORE

  4. 3. Genetic code expansion and dCas9-DAXXHBD as synthetic routes for epigenome editing

    University essay from Högskolan i Skövde/Institutionen för hälsovetenskaper

    Author : Michael Schrempf; [2020]
    Keywords : ;

    Abstract : Epigenome editing has become a promising new tool to study the effects of singular histone modifications on the transcriptional activity of mammalian cells. Although many different approaches have been developed during the recent years many approaches used dCas9 fused epigenetic effector proteins to deposit the epigenetic mark at target sites. READ MORE

  5. 4. Epigenetiskt arv

    University essay from SLU/Dept. of Animal Breeding and Genetics

    Author : Moa Lindell; [2019]
    Keywords : epigenetik; epigenetisk nedärvning; epigenetiska mekanismer;

    Abstract : Epigenetik är den del av genetiken som behandlar förändringar i genuttryck som är oberoende av förändringar i DNA-sekvensen. Det som styr vilka gener som uttrycks och får effekt på fenotyp har studerats av forskare sedan 70-80-talet. READ MORE

  6. 5. Effects of acetylation and deacetylation inhibitors on DNA double strand breaks repair and cell survival

    University essay from Uppsala universitet/Institutionen för immunologi, genetik och patologi

    Author : Eugenia Kalliontzi; [2018]
    Keywords : ;

    Abstract : During treatment with ionizing radiation (IR), cells are killed mainly due to ionizing radiation caused acute damage to DNA, such as double-strand breaks, where opposite DNA strands in close proximity are cut. To counteract toxicity of double-strand breaks, cells have evolved DNA damage repair systems such as homologous recombination and non-homologous end joining. READ MORE