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Showing result 1 - 5 of 9 essays matching the above criteria.

  1. 1. Ligand-stimulated cleavage of PDGFR-beta

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Agni Karolina Tsiatsiou; [2023]
    Keywords : ;

    Abstract : Platelet-derived growth factor receptors (α and β) are included in the family of receptor tyrosine kinases (RTKs). The dimeric PDGF ligands bind to the PDGF receptors and this results in receptor dimerization, autophosphorylation, and thus activation. The autophosphorylated receptor dimer activates numerous signaling pathways. READ MORE

  3. 2. Development and Application of Analytical Tools for Calcium Signaling Dynamics in MDCK-II Cells

    University essay from KTH/Tillämpad fysik

    Author : Hanna Israelsson; [2023]
    Keywords : Cellpose 2.0; MDCKII; GCaMP6m; Gap Junctions; Calcium; Ouabain; Cellpose 2.0; MDCKII; GCaMP6m; Gap Junctions; Kalcium; Ouabain;

    Abstract : Calcium, a pivotal ion in various human signaling pathways, holds significant relevance in cancer research and treatment. Investigating the transmission of spontaneous calcium signals between cells and understanding how they are influenced by different treatments is therefore an interesting area of study. READ MORE

  4. 3. The role of gap junctions in coordination of intercellular Ca2+ signaling

    University essay from KTH/Tillämpad fysik

    Author : Emma Latron; [2023]
    Keywords : applied physics; biophysics; Calcium; MDCKII; Gap Junctions; signalling; Segmentation; Tillämpad fysik; Biofysik; Kalcium; MDCKII; Gap Junctions; signalering; segmentering;

    Abstract : Calcium ions are one of the most versatile signalling molecules. They are essential tothe proper functioning of various cellular processes in many different types of cells.The calcium signals have been studied in the past using ratiometric dyes like Fura-2. READ MORE

  5. 4. Structural basis of modulation by pH and calcium in a ligand-gated ion channel

    University essay from KTH/Genteknologi

    Author : Olivia Andén; [2021]
    Keywords : Pentameric ligand-gated ion channels; bacterial homolog; protein expression; protein purification; cryo-electron microscopy; data processing; protein structure; Pentamerisk ligandstyrd jonkanal; bakteriell homolog; proteinexpression; proteinrening; kryo-elektronmikroskopi;

    Abstract : Pentameriska ligandstyrda jonkanaler (pLGICs) är avgörande för omvandlingen av kemisk till elektrisk signalöverföring i djurs nervsystem. Dysfunktion i dessa kanaler har visat sig vara kopplad till flera sjukdomar inklusive epilepsi, schizofreni, Alzheimers och autism, vilket gör dem till en måltavla för en mängd olika läkemedel. READ MORE

  6. 5. Expression and Purification of Recombinant Human S100A8 and S100A9 for Characterization of Their Roles as Danger Signals

    University essay from Lunds universitet/Tillämpad biokemi

    Author : Rebecca Trang; [2015]
    Keywords : S100A9; DAMP; RAGE; TLR4; applied biochemistry; tillämpad biokemi; S100A8; Technology and Engineering;

    Abstract : The direct involvement of S100 calcium-binding proteins A8 (S100A8) and A9 (S100A9) in numerous human diseases have been discovered more than 20 years ago, and they have ever since emerged as a very potent biomarker. Increased levels of S100A8 and S100A9 have been found in inflammation and various cancers. READ MORE