Essays about: "cancer metabolism"

Showing result 1 - 5 of 27 essays containing the words cancer metabolism.

  1. 1. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

    University essay from Lunds universitet/Institutionen för immunteknologi

    Author : Johan Thorsson; [2023]
    Keywords : Biology and Life Sciences;

    Abstract : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. READ MORE

  3. 2. Structural and Functional Characterisation of the Human Mitochondrial Pyruvate Carrier

    University essay from Lunds universitet/Kemiska institutionen

    Author : Simon Gripvall; [2023]
    Keywords : biochemistry; complex; MPC; proteoliposomes; pyruvate; transport; Chemistry;

    Abstract : The metabolism of pyruvate in the cell is abnormally regulated in several human diseases, such as type-II diabetes, cancer and neurodegenerative disorders, in which the human mitochondrial pyruvate carrier (HuMPC) sits at a pivotal point. It transports pyruvate across the inner mitochondrial membrane and consists of two proteins, MPC1 and MPC2, and is a potential drug target against these diseases. READ MORE

  4. 3. Study of energy metabolism in fibrocytes frommyelofibrosis patients : - a comparison withhealthy individuals

    University essay from Örebro universitet/Institutionen för medicinska vetenskaper

    Author : Fanny Folkö; [2022]
    Keywords : ;

    Abstract : Introduction: Myelofibrosis is a rare and deadly disease where bone marrow fibrosisobstructs production of blood cells. Metabolic alterations in cancer cells are well researchedand considered a possible therapeutic target. Few studies have researched the same possibilityfor myelofibrosis. READ MORE

  5. 4. GSK-3 post-transcriptionally regulates TNF-α biosynthesis in THP-1 macrophages

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Raghad Alghazali; [2022]
    Keywords : ;

    Abstract : Few things are more fascinating than finding new interactions between previously unrelated pathways. Glycogen synthase kinase-3 (GSK-3), a ubiquitous kinase initially known for its role in regulating glycogen metabolism, has recently been found to be an indispensable regulator of the TLR4-mediated inflammatory response. READ MORE

  6. 5. Impact of insulin, glucagon and the I-G complex on cell viability and metabolism in Panc-1

    University essay from Högskolan i Skövde/Institutionen för hälsovetenskaper

    Author : Katarina Brantingson Skogfält; [2021]
    Keywords : ;

    Abstract : Cancer has been found not only to be a disease of genetic mutations, but also a metabolic state by which insulin and glucagon has an impact on cancer cells. Pancreatic adenocarcinoma (PDAC) is a highly lethal cancer with high risk of recurrence of cancer cells after cancer therapy treatment with a worse outcome. READ MORE