Essays about: "galectin-8N"

Found 2 essays containing the word galectin-8N.

1. 1. Exploring a unique pocket in Galectin-8N by the synthesis of D-galactoside-based benzimidazole inhibitors

   University essay from Lunds universitet/Centrum för analys och syntes

   Author : Sid Bartold; [2023]
   Keywords : organic chemistry; synthesis; gal; gal-8; gal-8N; galectin; galectin-8; galectin-8N; inhibitor; drug development; benzimidazole; galactoside; carbohydrate; carbohydrate chemistry; Suzuki-coupling; Chemistry;

   Abstract : Galectins are a family of glycan-binding proteins where galectin-8 is a part of the subgroup known as tandem-repeat type galectins. Galectin-8 is composed of two homologous CRDs, one N- and one C-terminal CRD. As it stands now, galectin-8N has been found to bind to a larger number of glycans than galectin-8C. READ MORE

3. 2. Crystallization, optimization, and crystal structure determination of ligands in complex with galectin-8N

   University essay from Lunds universitet/Kemiska institutionen

   Author : George Larsson; [2022]
   Keywords : Biochemistry; Structural Biochemistry; Galectin-8; Protein Crystallization; Chemistry;

   Abstract : This thesis focuses on the protein “galectin-8N” which is a lectin protein that takes part in several physiological functions such as inflammation, autophagy, cell migration, and more. The project has three objectives: to observe and increase the reproducibility of crystallization of two variants (wildtype and mutant) of the human protein galectin-8N and to analyze the binding site when three different novel ligands are each inserted. READ MORE