Essays about: "galectin"

Showing result 1 - 5 of 10 essays containing the word galectin.

  1. 1. Exploring a unique pocket in Galectin-8N by the synthesis of D-galactoside-based benzimidazole inhibitors

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Sid Bartold; [2023]
    Keywords : organic chemistry; synthesis; gal; gal-8; gal-8N; galectin; galectin-8; galectin-8N; inhibitor; drug development; benzimidazole; galactoside; carbohydrate; carbohydrate chemistry; Suzuki-coupling; Chemistry;

    Abstract : Galectins are a family of glycan-binding proteins where galectin-8 is a part of the subgroup known as tandem-repeat type galectins. Galectin-8 is composed of two homologous CRDs, one N- and one C-terminal CRD. As it stands now, galectin-8N has been found to bind to a larger number of glycans than galectin-8C. READ MORE

  3. 2. Design, synthesis, and evaluation of 1-phenylethanol and C2 threitol derivatives as non-pyranose galactose-mimicking inhibitors of Galectin-3

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Qrystal Cruz Giron; [2023]
    Keywords : Galectin-3; Galectin-3 inhibitor; 1-phenylethanol; C2 threitol derivative; galactose-mimicking inhibitor; organic chemistry; Chemistry;

    Abstract : Galectins are cytosolic protein family involved in several biological functions such as cell differentiation, cell migration and apoptosis amongst many others. Their presence is also substantial in diseases including acute inflammation, fibrosis, allergies, and cancer. READ MORE

  4. 3. Crystallization, optimization, and crystal structure determination of ligands in complex with galectin-8N

    University essay from Lunds universitet/Kemiska institutionen

    Author : George Larsson; [2022]
    Keywords : Biochemistry; Structural Biochemistry; Galectin-8; Protein Crystallization; Chemistry;

    Abstract : This thesis focuses on the protein “galectin-8N” which is a lectin protein that takes part in several physiological functions such as inflammation, autophagy, cell migration, and more. The project has three objectives: to observe and increase the reproducibility of crystallization of two variants (wildtype and mutant) of the human protein galectin-8N and to analyze the binding site when three different novel ligands are each inserted. READ MORE

  5. 4. The Effect of Using DMSO as a Cosolvent for Ligand Binding Studies

    University essay from Lunds universitet/Biofysikalisk kemi

    Author : Simon Birgersson; [2019]
    Keywords : Galectins; Nuclear Magnetic Resonance; NMR; Biophysical Chemistry; Relaxation; CPMG; ITC; Biofysikalisk Kemi; Kärnmagnetisk resonans; Technology and Engineering; Chemistry; Biology and Life Sciences;

    Abstract : DMSO sees common application as a solvent for studies of synthetic molecules in biological systems, in fields such as drug design. Despite this, the possibility and nature of solvent interactions with both synthetic ligand and their target macromolecules is widely unexamined. READ MORE

  6. 5. Automated Orienting of Water Molecules in Neutron Crystal Structures

    University essay from Lunds universitet/Kemiska institutionen

    Author : Axl Eriksson; [2019]
    Keywords : Teoretisk kemi; Theoretical chemistry; Crystallography; Neutron crystallography; X-ray crystallography; Phenix.refine; Method development; Model improvement; Chemistry;

    Abstract : A protein’s function is directly related to its structure, which is in a water medium where it is affected by hydrogen bonds and the hydrophobic effect. These interactions are in turn dependent on the water molecules’ orientations around the protein. Therefore, it is vital to have correct orientations for the water molecules. READ MORE