Essays about: "knock-in mouse model"

Found 2 essays containing the words knock-in mouse model.

1. 1. Characterization of biological role of FKBP51-HSP90 protein-protein interactions in novel knock-in mouse model

   University essay from KTH/Proteinvetenskap

   Author : Shaoxun Xie; [2022]
   Keywords : FK506-binding protein 51kDa; heat shock protein 90kDa; glucocorticoid signaling pathway; dexamethasone; knock-in mouse model; FK506-bindande protein 51kDa; värmechockprotein 90kDa; glucocorticoiders signalvägar; dexamethasone; knock-in musmodell;

   Abstract : Värmechockprotein 90 kDa (HSP90) bildar ett anmärkningsvärt komplicerat nätverk med en mängd olika cochaperones. Komplexet av FK506-bindande protein 51 kDa (FKBP51) och HSP90 förmedlar proteinveckning och funktion, främjar tau aggregation vid Alzheimers sjukdom och påverkar stressrelaterade störningar, fetma, typ två-diabetes, etc. READ MORE

3. 2. Generating large-scale conditional knock-in mouse models using CRISPR/Cas9 in embryonic stem

   University essay from SLU/Dept. of Animal Breeding and Genetics

   Author : Gus Rowan Mcfarlane; [2016]
   Keywords : CRISPR Cas9; conditional knock-in mice; transgenic mice; Fbxw7; colorectal cancer;

   Abstract : The discovery and repurposing of CRISPR/Cas9 has revolutionized the field of genome editing and allowed for the development of mouse models with unprecedented simplicity and speed. The application of CRISPR/Cas9 in mouse embryonic stem cells represents a highly efficient and wellestablished method for generating large-scale conditional knock-in mouse models. READ MORE