Essays about: "molecule"

Showing result 6 - 10 of 279 essays containing the word molecule.

  1. 6. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    University essay from Uppsala universitet/Analytisk kemi

    Author : Maryam Dost; [2024]
    Keywords : Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Abstract : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. READ MORE

  3. 7. Indocyanine-green fluorescence imaging to detect anastomotic insufficiency after esophagectomy

    University essay from Lunds universitet/Fysiska institutionen; Lunds universitet/Förbränningsfysik

    Author : Love Kildetoft; [2024]
    Keywords : Fluorescence; Imaging; Indocyanine-green; ICG; Esophageal cancer; Physics; Photonics; Image Analysis; Blood Perfusion; Anastomotic leakage; Anastomotic insufficiency; Physics and Astronomy;

    Abstract : This research project is concerned with the development of simulation models and image analysis algorithms, as well as instrumentation for characterizing anastomotic leakages after a patient has undergone surgery for esophageal cancer. Anastomotic leakage is a high-incidence complication after esophagectomy, a surgical procedure for esophageal cancer. READ MORE

  4. 8. Evaluating and optimizing Transformer models for predicting chemical reactions

    University essay from Göteborgs universitet/Institutionen för data- och informationsteknik

    Author : Siva Manohar Koki; Supriya Kancharla; [2023-10-23]
    Keywords : Chemformer; transformer; evaluation; explainable AI; fine-tuning; machine learning;

    Abstract : In this thesis, we assess the effectiveness of a transformer model specifically trained to predict chemical reactions. The model, named Chemformer, is a sequence-tosequence model that uses the transformer’s encoder and decoder stacks. READ MORE

  5. 9. Simulated molecular adder circuits on a surface of DNA : Studying the scalability of surface chemical reaction network digital logic circuits

    University essay from KTH/Skolan för elektroteknik och datavetenskap (EECS)

    Author : Jakob Arvidsson; [2023]
    Keywords : Surface chemical reaction networks; Molecular computing; DNA computing; Circuit simulation; Adders; Ytbundna kemiska reaktionsnätverk; Molekylär beräkning; DNA-beräkning; Kretssimulering; Additionskretsar;

    Abstract : The behavior of the Deoxyribonucleic Acid (DNA) molecule can be exploited to perform useful computation. It can also be ”programmed” using the language of Chemical Reaction Networks (CRNs). One specialized CRN construct is the Surface Chemical Reaction Network (SCRN). READ MORE

  6. 10. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    University essay from Uppsala universitet/Theranostics

    Author : Astrid Haraldsson; [2023]
    Keywords : PNA; pretargeting; cancer therapy; cytotoxic payload;

    Abstract : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. READ MORE