Essays about: "protein formulation"

Showing result 1 - 5 of 32 essays containing the words protein formulation.

  1. 1. Effects of mixed surfactant system on chemical and physical stability of human growth hormone

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Karnsinee Viriyayudhakorn; [2023]
    Keywords : human growth hormone; surfactant; refolding; protein stability; physical degradation; chemical degradation; pharmaceutical technology; Technology and Engineering;

    Abstract : In protein formulation, addition of surfactants is commonly executed to enhance product stability and shelf-life. The reason is that surfactants can protect proteins against surface-induced aggregation. However, the interaction between surfactant and protein depends on the type of surfactant used. READ MORE

  3. 2. Biopolymers processed and used as enzyme carriers

    University essay from KTH/Fiber- och polymerteknologi

    Author : Dániel Mészáros; [2023]
    Keywords : Biobased materials; plasticized sodium alginate; water stability; extraction kinetics; enzyme carrier; Biobaserade material; Mjukgjort natriumalginat; Vattenstabilitet; extraktionskinetik; Enzymbärare;

    Abstract : Syftet med detta masterprojekt var att undersöka möjligheten att använda biobaserat, mjukgjort natriumalginat (NaAlg) som enzymbärare. Alginaterna görs traditionellt bearbetbara genom att tillsätta olika mjukgörare, såsom polyoler (glycerol, sorbitol, etc.), i detta arbete användes glycerol. READ MORE

  4. 3. Exploring GPT models as biomedical knowledge bases : By evaluating prompt methods for extracting information from language models pre-trained on scientific articles

    University essay from KTH/Skolan för elektroteknik och datavetenskap (EECS)

    Author : Ebba Hellberg; [2023]
    Keywords : Language model; GPT; knowledge probing; information extraction; prompt methods; Språkmodell; GPT; kunskapsbas; informationsextraktion; prompt-metoder;

    Abstract : Scientific findings recorded in literature help continuously guide scientific advancements, but manual approaches to accessing that knowledge are insufficient due to the sheer quantity of information and data available. Although pre-trained language models are being explored for their utility as knowledge bases and structured data repositories, there is a lack of research for this application in the biomedical domain. READ MORE

  5. 4. Methods to study device induced aggregation of proteins

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Marie Therese von Wowern; [2023]
    Keywords : protein formulation; protein aggregation; insulin; silicone oil; syringe; shear stress; subvisible particle; size exclusion chromatography; flow imaging microscopy; pharmaceutical technology; Technology and Engineering;

    Abstract : This work developed a method for the investigation of how medical devices, such as syringes and needles, affect the formation of subvisible particles in a protein drug without excipients. Protein-based pharmaceuticals are well known to be sensitive to different kinds of stress, and exposure to stress during the use of this device is unavoidable. READ MORE

  6. 5. Study of surfactant-preservative and protein-preservative interactions in multi-dose injectable formulation

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Javier Lagares Martín; [2023]
    Keywords : Phenol; polysorbate 80; cloud point; somatropin; aggregation; titration; light scattering; salt; surfactant; preservative; protein; tonicity adjusting agents; multi-dose injectable formulation; pharmaceutical technology; Technology and Engineering;

    Abstract : Multidose injectable formulations require a preservative such as phenol to ensure sterility and protection against microbial contamination during clinical use. However, it is known that the interaction between these components and non-ionic surfactants such as polysorbate 80, also found in this type of formulations, present incompatibilities, which can lead to decreases in the efficacy of the product. READ MORE