Essays about: "role of WT"

Showing result 16 - 20 of 27 essays containing the words role of WT.

  1. 16. Huntingtin gene profiling, towards allele-specific treatment

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Mimmi Håkansson; [2020]
    Keywords : Huntington’s disease; huntingtin lowering; allele-selective; HD animal models; Huntingtons sjukdom; huntingtin sänkning; allel-specifik; Huntington djurmodeller;

    Abstract : Huntington diseases(HD) is a fatal autosomal neurodegenerative genetic disorder, caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, resulting in a toxic gain-of-function in the mutant huntingtin protein(mHTT). To date, there is no approved treatment to either cure or halt the course of HD. READ MORE

  3. 17. Fluorescent fusion proteins as probes to characterize tau fibril polymorphism

    University essay from Linköpings universitet/Kemi

    Author : Max Lindberg; [2019]
    Keywords : Alzheimer’s disease AD ; amyloids; FRET; tau; MAPT; fibrillation kinetics; seeding; fusion protein; EGFP; ECFP; EYFP; ThT; X-34; BTD14;

    Abstract : Alzheimer's disease (AD) is a large and growing problem and while we today lack a full understanding of this disease, we know that the protein tau and the amyloid fibrils it forms play a central role in its development. We also know that these fibrils can have different morphologies in different diseases and that fibrils produced in vitro not necessarily adopt any of the morphologies found in patients. READ MORE

  4. 18. Study of pitch bearings in wind turbines : a model based approach

    University essay from KTH/Maskinkonstruktion (Inst.)

    Author : Abhijith Sriram; [2018]
    Keywords : Contact simulation; Slewing Bearing; Pitch Bearing; Load distribution; Kontaktsimulering; Pitchlager; Lastfördelning;

    Abstract : Dagens samhälle går mot en livsstil som präglas av möjligheter att göra allt fler hållbara val. För att minska koldioxidavtrycket krävs en fortsatt stabil omställning till förnyelsebara energikällor, i vilken vindkraften har en betydande roll. READ MORE

  5. 19. Enzyme engineering of a haloacid dehalogenase-like phosphatase from Thermotoga neopolitana for optimization of substrate specificity

    University essay from Lunds universitet/Bioteknik (master)

    Author : Samuel Sutiono; [2016]
    Keywords : Catalytic efficiency; Haloacid dehalogenase-like hydrolase; Enzyme engineering; Thermal stability; Inhibition; biotechnology; bioteknik; Technology and Engineering;

    Abstract : Haloacid dehalogenase (HAD)-like hydrolases represent a vast superfamily characterised by their ability to form covalent enzyme-substrate intermediates facilitating the cleavage of C-Cl, C-P, or CO-P bonds. Within this work one member of this superfamily, HAD from Thermotoga neopolitana (HADTn) exhibiting a phosphatase (P-O bond cleavage) like activity was investigated in the context of altering the substrate specificity. READ MORE

  6. 20. Degradation mechanisms of UN and UN–10U3Si2 pellets of varying microstructure by comparative steam oxidation experiments

    University essay from KTH/Reaktorfysik

    Author : Selim Uygur; [2016]
    Keywords : Uranium Mononitride; Uranium Silicide; Composite; Steam degradation; corrosion mechanism;

    Abstract : During an extended LOCA in a LWR, the current UO2 fuel reaches very high temperatures and eventually melts, while the current Zircaloy fuel cladding oxidizes releasing hydrogen. These two consequences can lead to an unacceptable amount of radioactive release by presenting accident routes for containment failure. READ MORE