Dynamics in Boolean Networks

University essay from Linköpings universitet/Institutionen för teknik och naturvetenskap


In this thesis several random Boolean networks are simulated. Both completely computer generated network and models for biological networks are simulated. Several different tools are used to gain knowledge about the robustness. These tools are Derrida plots, noise analysis and mean probability for canalizing rules. Some simulations on how entropy works as an indicator on if a network is robust are also included. The noise analysis works by measuring the hamming distance between the state of the network when noise is applied and when no noise is applied. For many of the simulated networks two types of rules are applied: nested canalizing and flat distributed rules. The computer generated networks consists of two types of networks: scale-free and ER-networks. One of the conclusions in this report is that nested canalizing rules are often more robust than flat distributed rules. Another conclusion is that the mean probability for canalizing rules has, for flat distributed rules, a very dominating effect on if the network is robust or not. Yet another conclusion is that the probability distribution for indegrees, for flat distributed rules, has a strong effect on if a network is robust due to the connection between the probability distribution for indegrees and the mean probability for canalizing rules.

  AT THIS PAGE YOU CAN DOWNLOAD THE WHOLE ESSAY. (follow the link to the next page)