Essays about: "ADCC"

Found 3 essays containing the word ADCC.

  1. 1. Development of a reporter gene assay on an automated platform

    University essay from Lunds universitet/Beräkningskemi; Lunds universitet/Tillämpad biokemi

    Author : Fanny Redin; [2021]
    Keywords : Reporter gene assay; Automation; Svar Life Science; Immunogenicity; TNF-alpha; Applied biochemistry; Technology and Engineering; Biology and Life Sciences;

    Abstract : Biological drugs have the potential to trigger unwanted immunogenic responses in patients which might affect the efficacy and safety of the treatment. Evaluating the immunogenicity throughout the drug development process is therefore crucial. READ MORE

  3. 2. Characterization of rituximab-induced B cell depletion and infusion reactions in a human blood loop system

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Mikaela Zekarias; [2020]
    Keywords : Rituximab; CDC; ADCC; infusion reactions; blood loop assay; Fc engineering;

    Abstract : Introduction: Rituximab is a monoclonal antibody used to treat hematological malignancies. The antibody depletes CD20+ B cells via cytotoxic immune mechanisms, such as complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC), which is mainly induced by natural killer (NK) cells. READ MORE

  4. 3. Utveckling av lymfocytär thyreodit hos hund med fokus på immunologiska mekanismer

    University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Author : Elin Lundbeck; [2019]
    Keywords : hypothyroidism; lymfocytär thyreodit; hund; CTLA-­4; DLA; autoantikroppar; FoxP3; cytotoxiska T-­lymfocyter;

    Abstract : Lymfocytär thyreodit är en av de vanligaste endokrina sjukdomarna hos hund och uppkommer på grund av en autoimmun reaktion mot thyroidea. Det resulterar i att körteln bryts ned och nivåerna av thyroideahormoner i kroppen minskar. READ MORE