Essays about: "gene knockout"

Showing result 6 - 10 of 23 essays containing the words gene knockout.

  1. 6. A pericyte-specific knockout of Foxf2 in mice shows fibrinogen acculumation in the brain but no regulation in Pdgfr-ß expression

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Ebba Stål; [2021]
    Keywords : ;

    Abstract : FoxF2 is a transcriptional factor that initiates gene expression. Foxf2 is particularly expressed in central nervous system pericytes. Recent studies have displayed that an inactivation of Foxf2 in mice had an impact on the blood-brain barrier integrity with evidence of breakdown. READ MORE

  3. 7. Knockout studies of Panc1 cells

    University essay from KTH/Tillämpad fysik

    Author : Martin Sundin; [2021]
    Keywords : PDAC; crosstalk; stroma; spheroid; western blot; viability; gemcitabine.; PDAC;  verh rning; stroma; sf roid; western blot; viabilitet; gemcitabine.;

    Abstract : Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancerwith very few available treatment options of which none has great effect.Cancer cells and stromal cells such as stellate cells which exist in abundancein PDAC interact by crosstalk, resulting in a tumorigenic collective response. READ MORE

  4. 8. Exploring the impact of estrogen signaling on gut microbiota diversity in a diet-induced obesity and a colorectal cancer model

    University essay from KTH/Proteinvetenskap

    Author : Lina Stepanauskaite; [2021]
    Keywords : colorectal cancer; gut microbiome; whole genome analysis; estrogen; high-fat diet;

    Abstract : Colorectal cancer (CRC) is one of the most common and deadly cancers in the western world. The incidence of CRC shows the tendency to rise with the increase of obesity, which is caused by current increase in fat intake, suggesting the correlation between CRC and high-fat diet (HFD). READ MORE

  5. 9. Functional characterization of the SLC38 transporters SNAT6, SNAT8 and SNAT10 using CRISPR-Cas9 knockout in vitro

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Alfred Holmberg; [2020]
    Keywords : SNAT6; SNAT8; SNAT10; SLC38; SLC38a6; SLC38a8; SLC38a10; CRISPR-Cas9; crispr; glutamate-glutamine cycle; ggc; glutamate; glutamine; gaba; hek293;

    Abstract : There are currently over 430 known SLC transporters, over 30% of which have an unknown function. Compared to other transporter gene families, the SLC genes are relatively understudied with many orphan genes. READ MORE

  6. 10. NLRP INFLAMMASOME : CRISPR knockout of RIPK3 gene in THP-1 monocytes

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Ryan Potter; [2020]
    Keywords : ;

    Abstract : Inflammation is a biological response to harmful stimuli which assists the overall immune response in defending the organism against potential threats like bacteria and other pathogens. This response is largely regulated by multiprotein complexes known as inflammasomes, which use one or more multi-stage networks to create a coordinated response across cell groups. READ MORE