Essays about: "gene knockout"
Showing result 16 - 20 of 23 essays containing the words gene knockout.
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16. Towards Identifying Pharmacodynamic Blood Biomarkers of MAP3K12 Inhibition
University essay from Lunds universitet/Tillämpad biokemiAbstract : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons in the brain and spinal cord, for which there is no cure. Activation of the stress-induced c-Jun N-terminal kinase (JNK) signaling pathway, a critical mediator of neuronal apoptosis and axon degeneration, is evident in ALS and is therefore considered a potential target to prevent neurodegeneration. READ MORE
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17. Development of a CRISPR systemfor gene knockouts in Diplomonad parasites
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : This thesis describes the attempt to implement the CRISPR-Cas9 system in the two diplomonad pathogens: Giardia intestinalis and Spironucleus salmonicida. Two approaches of the implementation were done: first the Cas9 was expressed, followed by expression of the guide RNA. READ MORE
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18. The WT1-gene – its role in tumourigenesis and prospects for developing a vaccine
University essay from SLU/Dept. of Animal Nutrition and ManagementAbstract : The WT1 gene is a complex gene originally known to suppress cancer in kidneys. Studies of WT1 knockout mice have confirmed the important role of WT1 in the pathogenesis of Wilms’ tumour, a tumour which counts for 95% of all childhood renal tumours. In that case the WT1 gene acts as a tumour suppressor gene. READ MORE
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19. Expression of weight and aggression regulating genes in Drosophila melanogaster after exposure to the behavioural pheromone 11-cis-vaccenyl acetate
University essay from Institutionen för kvinnors och barns hälsaAbstract : Obesity is a growing public health issue with few effective treatments. Many of the human genes involved in weight regulation have homologues in other species. In Drosophila melanogaster, 11-cis-vaccenyl acetate (cVA) is a pheromone shown to affect both aggression and feeding behaviour. READ MORE
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20. Programmed cell death in the moss Physcomitrella patens : studying the role of metacaspases in archegonia development through gene knockout by homologous recombination
University essay from SLU/Dept. of Plant Biology and Forest Genetics (until 131231)Abstract : The knowledge of programmed cell death (PCD) in plants is limited. The gene family of caspases in animals is known to be important for the execution of PCD. Putative homologues to caspases have been found in plants and are referred to as metacaspases. READ MORE
